P-HYDOROXYPHENYL-4-BUTANOL

Base Information

• Chemical Name: P-HYDOROXYPHENYL-4-BUTANOL
• CAS No.: 86223-05-4
• Molecular Formula: C10H14 O2
• Molecular Weight: 166.22
• Hs Code.: 2907299090
• Mol file: 86223-05-4.mol

Synonyms:4-(4-Hydroxyphenyl)-1-butanol;4-(4-Hydroxyphenyl)butanol;1-Butanol,4-(p-hydroxyphenyl)- (6CI,7CI);4-(4-Hydroxybutyl)phenol;

Chemical Property of P-HYDOROXYPHENYL-4-BUTANOL

Chemical Property:

• PSA: 40.46000
• LogP: 1.70720

Purity/Quality:

98%, ^*data from raw suppliers

4-(4-Hydroxybutyl)phenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-(4-Hydroxybutyl)phenol acts as a reagent in the discovery of quinoline based single-ligand human H1 and H3 receptor antagonist for treatment of allergic rhinitis associated with nasal congestion.

Technology Process of P-HYDOROXYPHENYL-4-BUTANOL

There total 12 articles about P-HYDOROXYPHENYL-4-BUTANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

4-(4-methoxyphenyl)butan-1-ol (52244-70-9,239474-80-7) → 4-(4-hydroxyphenyl)butanol (86223-05-4)

Guidance literature:

With sodium hydroxide; boron tribromide; In dichloromethane; ethyl acetate;

Reference yield: 85.0%

4-(4-hydroxyphenyl)butyl acetate (1615654-57-3) → 4-(4-hydroxyphenyl)butanol (86223-05-4)

Guidance literature:

With sodium hydroxide; In methanol; at 20 ℃; for 2h;

Reference yield: 77.0%

4-(3,5-di-tert-butyl-4-hydroxyphenyl)butanol (3673-69-6) → 4-(4-hydroxybutyl)-2-tert-butylphenol (552314-65-5) + di[4-(2-tert-butyl-4-hydroxyphenyl)butyl] ether + 4-(4-hydroxyphenyl)butanol (86223-05-4)

Guidance literature:

at 290 - 295 ℃; for 8h; Inert atmosphere;

DOI:10.1134/S1070363210020167

upstream raw materials:

Butane-1,4-diol

phenol

4-(4-methoxyphenyl)butan-1-ol

4-(4-benzyloxyphenyl)-3-buten-1-ol

Downstream raw materials:

2,6-dibromo-4-(4-hydroxy-butyl)-phenol

3-<<4-(4-hydroxybutyl)phenoxy>methyl>-2-thiophenecarboxylic acid

1-benzyloxy-4-(4-hydroxybutyl)benzene

4-(4-hydroxyphenyl)butyl bromide