(S)-1-(1-(4-chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((2-methylpyrimidin-4-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one

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Chemical Name:(S)-1-(1-(4-chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((2-methylpyrimidin-4-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one
CAS No.:1453848-03-7
Molecular Formula:C₂₂H₁₈ClFN₆O₂
Molecular Weight:452.875
Hs Code.:

Synonyms:(S)-1-(1-(4-chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((2-methylpyrimidin-4-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one

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Chemical Property of (S)-1-(1-(4-chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((2-methylpyrimidin-4-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one

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Technology Process of (S)-1-(1-(4-chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((2-methylpyrimidin-4-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one

There total 11 articles about (S)-1-(1-(4-chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((2-methylpyrimidin-4-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.0%

: 1453853-24-1
(S)-1-(2-(tert-butyldimethylsilyloxy)-1-(4-chloro-3-fluorophenyl)ethyl)-4-(2-((2-methylpyrimidin-4-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one

: 1453848-03-7
(S)-1-(1-(4-chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((2-methylpyrimidin-4-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 1h;

Reference yield:

: 5527-95-7
4-chloro-3-fluorobenzaldehyde

: 1453848-03-7
(S)-1-(1-(4-chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((2-methylpyrimidin-4-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hydride / mineral oil; tetrahydrofuran / 0 - 20 °C

2.1: AD-mix-β / water; tert-butyl alcohol / 0 - 20 °C

3.1: 1H-imidazole / dichloromethane / 1 h / 0 °C

4.1: triethylamine / dichloromethane / 0.5 h / 0 °C

5.1: potassium hexamethylsilazane / tetrahydrofuran / 0.17 h / 0 °C

5.2: 30 h / 20 °C

6.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 0 °C

7.1: iso-butanol / 18 h / 110 °C / Sealed tube

8.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

With 1H-imidazole; AD-mix-β; tetrabutyl ammonium fluoride; potassium hexamethylsilazane; sodium hydride; triethylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane; water; iso-butanol; mineral oil; tert-butyl alcohol; 1.1: |Wittig Rearrangement;

Reference yield:

: 1263414-46-5
1-chloro-2-fluoro-4-vinylbenzene

: 1453848-03-7
(S)-1-(1-(4-chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((2-methylpyrimidin-4-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: AD-mix-β / water; tert-butyl alcohol / 0 - 20 °C

2.1: 1H-imidazole / dichloromethane / 1 h / 0 °C

3.1: triethylamine / dichloromethane / 0.5 h / 0 °C

4.1: potassium hexamethylsilazane / tetrahydrofuran / 0.17 h / 0 °C

4.2: 30 h / 20 °C

5.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 0 °C

6.1: iso-butanol / 18 h / 110 °C / Sealed tube

7.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

With 1H-imidazole; AD-mix-β; tetrabutyl ammonium fluoride; potassium hexamethylsilazane; triethylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane; water; iso-butanol; tert-butyl alcohol;