1,2-Ethanediol, 1-(4-chloro-3-fluorophenyl)-, (1R)-

Base Information

Chemical Name:1,2-Ethanediol, 1-(4-chloro-3-fluorophenyl)-, (1R)-
CAS No.:1453854-84-6
Molecular Formula:C₈H₈ClFO₂
Molecular Weight:190.602
Hs Code.:2906290090
Mol file:1453854-84-6.mol

Synonyms:(R)-1-(4-chloro-3-fluorophenyl)ethane-1,2-diol

Suppliers and Price of 1,2-Ethanediol, 1-(4-chloro-3-fluorophenyl)-, (1R)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(1R)-1-(4-Chloro-3-fluorophenyl)-1,2-ethanediol
5mg
$ 65.00

ChemScene
1,2-Ethanediol,1-(4-chloro-3-fluorophenyl)-,(1R)- 99.67%
500mg
$ 850.00

Apolloscientific
(R)-1-(4-Chloro-3-fluorophenyl)ethane-1,2-diol 95%
500mg
$ 1224.00

Alichem
(R)-1-(4-Chloro-3-fluorophenyl)ethane-1,2-diol
5g
$ 690.90

Total 7 raw suppliers

Chemical Property of 1,2-Ethanediol, 1-(4-chloro-3-fluorophenyl)-, (1R)-

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

(1R)-1-(4-Chloro-3-fluorophenyl)-1,2-ethanediol ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1,2-Ethanediol, 1-(4-chloro-3-fluorophenyl)-, (1R)-

There total 3 articles about 1,2-Ethanediol, 1-(4-chloro-3-fluorophenyl)-, (1R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1-(4-chloro-3-fluorophenyl)-2-hydroxyethanone

: 1453854-84-6
(R)-1-(4-chloro-3-fluorophenyl)ethane-1,2-diol

Guidance literature:: With dextrose monohydrate; 4-morpholineethanesulfonic acid; glucose dehydrogenase 105; ketoreductase NADH-112; NAD; magnesium chloride; In n-heptane; water; at 29 - 31 ℃; for 24h; pH=6.5 - 7; Reagent/catalyst; enantioselective reaction; Inert atmosphere; Large scale;
DOI:10.1021/acs.oprd.7b00006

Reference yield: 64.0%

: 1263414-46-5
1-chloro-2-fluoro-4-vinylbenzene

: 1453854-84-6
(R)-1-(4-chloro-3-fluorophenyl)ethane-1,2-diol

Guidance literature:: With AD-mix β; In water; tert-butyl alcohol; at 25 ℃; for 16h;
DOI:10.1021/jm501921k

Reference yield:

: 860029-79-4
2-chloro-1-(4-chloro-3-fluorophenyl)ethanone

: 1453854-84-6
(R)-1-(4-chloro-3-fluorophenyl)ethane-1,2-diol

Guidance literature:: Multi-step reaction with 2 steps

1: formic acid; sodium formate / ethanol; water / 15 °C / Inert atmosphere; Reflux; Large scale

2: 4-morpholineethanesulfonic acid; magnesium chloride; sodium hydroxide; glucose dehydrogenase GDH-105; nicotinamide adenine dinucleotide; oxidoreductase KRED-NADH-112; D-glucose / water; n-heptane / 29 - 31 °C / pH 6.5 - 7 / Inert atmosphere; Large scale; Enzymatic reaction

With formic acid; 4-morpholineethanesulfonic acid; D-glucose; nicotinamide adenine dinucleotide; glucose dehydrogenase GDH-105; oxidoreductase KRED-NADH-112; sodium formate; sodium hydroxide; magnesium chloride; In ethanol; n-heptane; water;