1-ethyl-6,7-bis((4-methoxybenzyl)oxy)-4-oxo-1,4-dihydrocinnolin-3-carbaldehyde

Base Information

Chemical Name:1-ethyl-6,7-bis((4-methoxybenzyl)oxy)-4-oxo-1,4-dihydrocinnolin-3-carbaldehyde
CAS No.:1429438-93-6
Molecular Formula:C₂₇H₂₆N₂O₆
Molecular Weight:474.513
Hs Code.:

Synonyms:1-ethyl-6,7-bis((4-methoxybenzyl)oxy)-4-oxo-1,4-dihydrocinnolin-3-carbaldehyde

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Chemical Property of 1-ethyl-6,7-bis((4-methoxybenzyl)oxy)-4-oxo-1,4-dihydrocinnolin-3-carbaldehyde

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Technology Process of 1-ethyl-6,7-bis((4-methoxybenzyl)oxy)-4-oxo-1,4-dihydrocinnolin-3-carbaldehyde

There total 5 articles about 1-ethyl-6,7-bis((4-methoxybenzyl)oxy)-4-oxo-1,4-dihydrocinnolin-3-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.5%

: 1429438-92-5
1-ethyl-3-(hydroxymethyl)-6,7-bis((4-methoxybenzyl)oxy)cinnolin-4(1H)-one

: 1429438-93-6
1-ethyl-6,7-bis((4-methoxybenzyl)oxy)-4-oxo-1,4-dihydrocinnolin-3-carbaldehyde

Guidance literature:: With Dess-Martin periodane; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;

Reference yield:

: 1429438-90-3
methyl 1-ethyl-6,7-bis((4-methoxybenzyl)oxy)-4-oxo-1,4-dihydrocinnolin-3-carboxylate

: 1429438-93-6
1-ethyl-6,7-bis((4-methoxybenzyl)oxy)-4-oxo-1,4-dihydrocinnolin-3-carbaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium hydroxide / methanol; water / 1.5 h / Inert atmosphere; Reflux

1.2: 20 °C / pH 1 / Inert atmosphere

2.1: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

2.2: 2 h / 20 °C / Inert atmosphere

3.1: Dess-Martin periodane / dichloromethane / 1 h / 20 °C / Inert atmosphere

With chloroformic acid ethyl ester; Dess-Martin periodane; triethylamine; potassium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water;

Reference yield:

: 1429438-89-0
methyl 1-ethyl-6,7-dihydroxy-4-oxo-1,4-dihydrocinnolin-3-carboxylate

: 1429438-93-6
1-ethyl-6,7-bis((4-methoxybenzyl)oxy)-4-oxo-1,4-dihydrocinnolin-3-carbaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate; potassium iodide / acetone / Inert atmosphere; Reflux

2.1: potassium hydroxide / methanol; water / 1.5 h / Inert atmosphere; Reflux

2.2: 20 °C / pH 1 / Inert atmosphere

3.1: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

3.2: 2 h / 20 °C / Inert atmosphere

4.1: Dess-Martin periodane / dichloromethane / 1 h / 20 °C / Inert atmosphere

With chloroformic acid ethyl ester; potassium carbonate; Dess-Martin periodane; triethylamine; potassium iodide; potassium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; acetone;