1-ethyl-3-(hydroxymethyl)-6,7-bis((4-methoxybenzyl)oxy)cinnolin-4(1H)-one

Base Information

Chemical Name:1-ethyl-3-(hydroxymethyl)-6,7-bis((4-methoxybenzyl)oxy)cinnolin-4(1H)-one
CAS No.:1429438-92-5
Molecular Formula:C₂₇H₂₈N₂O₆
Molecular Weight:476.529
Hs Code.:

Synonyms:1-ethyl-3-(hydroxymethyl)-6,7-bis((4-methoxybenzyl)oxy)cinnolin-4(1H)-one

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Chemical Property of 1-ethyl-3-(hydroxymethyl)-6,7-bis((4-methoxybenzyl)oxy)cinnolin-4(1H)-one

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Technology Process of 1-ethyl-3-(hydroxymethyl)-6,7-bis((4-methoxybenzyl)oxy)cinnolin-4(1H)-one

There total 4 articles about 1-ethyl-3-(hydroxymethyl)-6,7-bis((4-methoxybenzyl)oxy)cinnolin-4(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1429438-91-4
1-ethyl-6,7-bis((4-methoxybenzyl)oxy)-4-oxo-1,4-dihydrocinnolin-3-carboxylic acid

: 1429438-92-5
1-ethyl-3-(hydroxymethyl)-6,7-bis((4-methoxybenzyl)oxy)cinnolin-4(1H)-one

Guidance literature:: 1-ethyl-6,7-bis((4-methoxybenzyl)oxy)-4-oxo-1,4-dihydrocinnolin-3-carboxylic acid; With chloroformic acid ethyl ester; triethylamine; In tetrahydrofuran; at 20 ℃; for 2h; Inert atmosphere;

With sodium tetrahydroborate; In tetrahydrofuran; ethanol; at 20 ℃; for 2h; Inert atmosphere;

Reference yield:

: 1429438-90-3
methyl 1-ethyl-6,7-bis((4-methoxybenzyl)oxy)-4-oxo-1,4-dihydrocinnolin-3-carboxylate

: 1429438-92-5
1-ethyl-3-(hydroxymethyl)-6,7-bis((4-methoxybenzyl)oxy)cinnolin-4(1H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium hydroxide / methanol; water / 1.5 h / Inert atmosphere; Reflux

1.2: 20 °C / pH 1 / Inert atmosphere

2.1: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

2.2: 2 h / 20 °C / Inert atmosphere

With chloroformic acid ethyl ester; triethylamine; potassium hydroxide; In tetrahydrofuran; methanol; water;

Reference yield:

: 1429438-89-0
methyl 1-ethyl-6,7-dihydroxy-4-oxo-1,4-dihydrocinnolin-3-carboxylate

: 1429438-92-5
1-ethyl-3-(hydroxymethyl)-6,7-bis((4-methoxybenzyl)oxy)cinnolin-4(1H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate; potassium iodide / acetone / Inert atmosphere; Reflux

2.1: potassium hydroxide / methanol; water / 1.5 h / Inert atmosphere; Reflux

2.2: 20 °C / pH 1 / Inert atmosphere

3.1: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

3.2: 2 h / 20 °C / Inert atmosphere

With chloroformic acid ethyl ester; potassium carbonate; triethylamine; potassium iodide; potassium hydroxide; In tetrahydrofuran; methanol; water; acetone;