4-(tert-Butyl-dimethyl-silanyloxymethyl)-pyridin-2-ylamine

Base Information

Chemical Name:4-(tert-Butyl-dimethyl-silanyloxymethyl)-pyridin-2-ylamine
CAS No.:329794-09-4
Molecular Formula:C12H22 N2 O Si
Molecular Weight:238.405
Hs Code.:2933399090
DSSTox Substance ID:DTXSID70457305
Wikidata:Q82280108
Mol file:329794-09-4.mol

Synonyms:329794-09-4;4-(tert-Butyl-dimethyl-silanyloxymethyl)-pyridin-2-ylamine;4-(((tert-Butyldimethylsilyl)oxy)methyl)pyridin-2-amine;4-[[tert-butyl(dimethyl)silyl]oxymethyl]pyridin-2-amine;2-amino-4-(tert-butyldimethylsilyloxymethyl)pyridine;SCHEMBL331281;DTXSID70457305;JMNHDECXCXSHHT-UHFFFAOYSA-N;MFCD06800385;2-PYRIDINAMINE, 4-[[[(1,1-DIMETHYLETHYL)DIMETHYLSILYL]OXY]METHYL]-;AKOS015956037;FT-0677401;A821542;A1-32248;4-tert-Butyldimethylsilanyloxymethyl)pyridin-2-ylamine;4-({[tert-butyl(dimethyl)silyl]oxy}methyl)pyridin-2-amine;4-(tert-Butyl-dimethyl-silanyloxymethyl)-pyridin-2-ylamine, AldrichCPR

Suppliers and Price of 4-(tert-Butyl-dimethyl-silanyloxymethyl)-pyridin-2-ylamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Sigma-Aldrich
4-(tert-Butyl-dimethyl-silanyloxymethyl)-pyridin-2-ylamine Aldrich
1g
$ 168.00

Matrix Scientific
4-(tert-Butyl-dimethyl-silanyloxymethyl)-pyridin-2-ylamine
500mg
$ 121.00

Crysdot
4-(((tert-Butyldimethylsilyl)oxy)methyl)pyridin-2-amine 95+%
5g
$ 678.00

Crysdot
4-(((tert-Butyldimethylsilyl)oxy)methyl)pyridin-2-amine 95+%
10g
$ 1171.00

Crysdot
4-(((tert-Butyldimethylsilyl)oxy)methyl)pyridin-2-amine 95+%
1g
$ 226.00

Chemenu
4-(((tert-Butyldimethylsilyl)oxy)methyl)pyridin-2-amine 95%
1g
$ 213.00

Chemenu
4-(((tert-Butyldimethylsilyl)oxy)methyl)pyridin-2-amine 95%
10g
$ 1103.00

Chemenu
4-(((tert-Butyldimethylsilyl)oxy)methyl)pyridin-2-amine 95%
5g
$ 640.00

American Custom Chemicals Corporation
4-(TERT-BUTYL-DIMETHYL-SILANYLOXYMETHYL)-PYRIDIN-2-YLAMINE 95.00%
500MG
$ 254.10

Alichem
4-(((tert-Butyldimethylsilyl)oxy)methyl)pyridin-2-amine
10g
$ 1180.00

Total 16 raw suppliers

Chemical Property of 4-(tert-Butyl-dimethyl-silanyloxymethyl)-pyridin-2-ylamine

Chemical Property:

Vapor Pressure:0.000315mmHg at 25°C
Melting Point:109.2-109.3°C
Boiling Point:320.6 ºC at 760 mmHg
Flash Point:147.7 ºC
PSA：48.14000
Density:0.983 g/cm³
LogP:3.76680
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:238.150139864
Heavy Atom Count:16
Complexity:226

Purity/Quality:

97% ^*data from raw suppliers

4-(tert-Butyl-dimethyl-silanyloxymethyl)-pyridin-2-ylamine Aldrich ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xi

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)[Si](C)(C)OCC1=CC(=NC=C1)N

Technology Process of 4-(tert-Butyl-dimethyl-silanyloxymethyl)-pyridin-2-ylamine

There total 5 articles about 4-(tert-Butyl-dimethyl-silanyloxymethyl)-pyridin-2-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 105250-17-7
2-amino-4-hydroxymethylpyridine

: 329794-09-4
4-({[tert-butyl(dimethyl)silyl]oxy}methyl)pyridin-2-amine

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 14h;

Reference yield:

: benzhydrylidene-[4-(tert-butyl-dimethyl-silanyloxymethyl)-pyridin-2-yl]-amine

: 329794-09-4
4-({[tert-butyl(dimethyl)silyl]oxy}methyl)pyridin-2-amine

Guidance literature:: With hydroxylamine; In methanol; at 20 ℃; for 18h;
DOI:10.1021/jm049697f

Reference yield:

: 100704-10-7
(2-chloropyridin-4-yl)methanol

: 329794-09-4
4-({[tert-butyl(dimethyl)silyl]oxy}methyl)pyridin-2-amine

Guidance literature:: Multi-step reaction with 3 steps

1: 97 percent / imidazole / tetrahydrofuran / 24 h / 20 °C

2: NaOtBu; BINAP racemic; Pd₂(dba)3 / toluene / 5 h / 80 °C

3: 17.89 g / aq. hydroxylamine / methanol / 18 h / 20 °C

With 1H-imidazole; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; hydroxylamine; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; In tetrahydrofuran; methanol; toluene;
DOI:10.1021/jm049697f