2-Fluorobenzamidine hydrochloride

Base Information

• Chemical Name: 2-Fluorobenzamidine hydrochloride
• CAS No.: 57075-81-7
• Molecular Formula: C7H7 F N2 . Cl H
• Molecular Weight: 174.605
• Hs Code.: 2925290090
• Mol file: 57075-81-7.mol

Synonyms:Benzenecarboximidamide,2-fluoro-, monohydrochloride (9CI); 2-Fluorobenzamidine hydrochloride; 2-Fluorobenzenecarboximidamidehydrochloride; o-Fluorobenzamidine hydrochloride

Chemical Property of 2-Fluorobenzamidine hydrochloride

Chemical Property:

• Vapor Pressure: 0.183mmHg at 25°C
• Melting Point: 98-100 °C(Solv: ethyl ether (60-29-7))
• Boiling Point: 211.4°C at 760 mmHg
• Flash Point: 81.6°C
• PSA: 49.87000
• LogP: 2.71180
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

2-FluorobenzimidamideHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Fluorobenzamidine hydrochloride

There total 4 articles about 2-Fluorobenzamidine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

2-fluorobenzonitrile (394-47-8) → 2-fluorobenzene-1-carboximidamide hydrogen chloride (57075-81-7)

Guidance literature:

With lithium hexamethyldisilazane; In tetrahydrofuran; at 20 ℃; for 4h;

DOI:10.1002/ejoc.200600060

Reference yield: 80.0%

→ 2-fluorobenzene-1-carboximidamide hydrogen chloride (57075-81-7)

Guidance literature:

Reference yield:

2-fluorobenzonitrile (394-47-8) + lithium hexamethyldisilazane (4039-32-1) → 2-fluorobenzene-1-carboximidamide hydrogen chloride (57075-81-7)

Guidance literature:

With hydrogenchloride; In ethanol;

upstream raw materials:

2-fluorobenzonitrile

lithium hexamethyldisilazane

Downstream raw materials:

(2-(2-fluorophenyl)-1H-imidazol-5-yl)methanol

5-chloromethyl-2-(2-fluorophenyl)-1H-imidazole

Refernces

• 1、 -. "PYRIMIDINE CARBOXYLIC ACID DERIVATIVES AND USE THEREOF". Page/Page column 34. . Retrieved 2010/11/23.
• 2、 -. "Triazole derivatives". . . Retrieved 2011/03/17.