(S)-3-cyclohexyl-2-(4-fluoro-1-oxo-1,3-dihydro-isoindol-2-yl)-N-[1-(2-methoxy-ethyl)-1H-pyrazol-3-yl]-propionamide

Base Information

Chemical Name:(S)-3-cyclohexyl-2-(4-fluoro-1-oxo-1,3-dihydro-isoindol-2-yl)-N-[1-(2-methoxy-ethyl)-1H-pyrazol-3-yl]-propionamide
CAS No.:1407232-87-4
Molecular Formula:C₂₃H₂₉FN₄O₃
Molecular Weight:428.507
Hs Code.:

Synonyms:(S)-3-cyclohexyl-2-(4-fluoro-1-oxo-1,3-dihydro-isoindol-2-yl)-N-[1-(2-methoxy-ethyl)-1H-pyrazol-3-yl]-propionamide

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Chemical Property of (S)-3-cyclohexyl-2-(4-fluoro-1-oxo-1,3-dihydro-isoindol-2-yl)-N-[1-(2-methoxy-ethyl)-1H-pyrazol-3-yl]-propionamide

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Technology Process of (S)-3-cyclohexyl-2-(4-fluoro-1-oxo-1,3-dihydro-isoindol-2-yl)-N-[1-(2-methoxy-ethyl)-1H-pyrazol-3-yl]-propionamide

There total 6 articles about (S)-3-cyclohexyl-2-(4-fluoro-1-oxo-1,3-dihydro-isoindol-2-yl)-N-[1-(2-methoxy-ethyl)-1H-pyrazol-3-yl]-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 899899-20-8
1-(2-Methoxy-ethyl)-1H-pyrazol-3-yl amine

: C₁₇H₁₉ClFNO₂

: 1407232-87-4
(S)-3-cyclohexyl-2-(4-fluoro-1-oxo-1,3-dihydro-isoindol-2-yl)-N-[1-(2-methoxy-ethyl)-1H-pyrazol-3-yl]-propionamide

Guidance literature:: With 2,6-dimethylpyridine; In dichloromethane; at 0 - 20 ℃; for 16h; Inert atmosphere;

Reference yield:

: 230301-81-2
methyl 3-fluoro-2-methylbenzoate

: 1407232-87-4
(S)-3-cyclohexyl-2-(4-fluoro-1-oxo-1,3-dihydro-isoindol-2-yl)-N-[1-(2-methoxy-ethyl)-1H-pyrazol-3-yl]-propionamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-Bromosuccinimide / dibenzoyl peroxide / tetrachloromethane / 3 h / Inert atmosphere; Reflux

2.1: triethylamine / acetonitrile / 16 h / 82 °C / Inert atmosphere

3.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 2 h / 20 °C

3.2: pH 2

4.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0.75 h / 0 - 20 °C / Inert atmosphere

5.1: 2,6-dimethylpyridine / dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere

With 2,6-dimethylpyridine; N-Bromosuccinimide; oxalyl dichloride; lithium hydroxide monohydrate; water; triethylamine; N,N-dimethyl-formamide; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; dichloromethane; acetonitrile;

Reference yield:

: 142314-72-5
2-Bromomethyl-3-fluoro-benzoic acid methyl ester

: 1407232-87-4
(S)-3-cyclohexyl-2-(4-fluoro-1-oxo-1,3-dihydro-isoindol-2-yl)-N-[1-(2-methoxy-ethyl)-1H-pyrazol-3-yl]-propionamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / acetonitrile / 16 h / 82 °C / Inert atmosphere

2.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 2 h / 20 °C

2.2: pH 2

3.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0.75 h / 0 - 20 °C / Inert atmosphere

4.1: 2,6-dimethylpyridine / dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere

With 2,6-dimethylpyridine; oxalyl dichloride; lithium hydroxide monohydrate; water; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; acetonitrile;