142314-72-5

Usage

Uses

Used in Pharmaceutical Industry:
METHYL 2-BROMOMETHYL-3-FLUORO-BENZOATE is used as a chemical intermediate for the synthesis of various pharmaceutical drugs. Its benzoate group contributes to the antimicrobial and antifungal properties of these drugs, making it a valuable component in the development of new medications.
Used in Chemical Research:
METHYL 2-BROMOMETHYL-3-FLUORO-BENZOATE is used as a specialized reagent in various chemical reactions within laboratory settings. Its unique structure with bromine and fluorine atoms allows for the exploration of different chemical pathways and the synthesis of new compounds.
Used in Material Science:
METHYL 2-BROMOMETHYL-3-FLUORO-BENZOATE is used as a building block in the development of new materials with specific properties. The presence of bromine and fluorine atoms in its structure can influence the physical and chemical characteristics of the materials, making it a useful component in material science research.

Upstream product

• 699-90-1 3-fluoro-2-methylbenzoic acid 
• 230301-81-2 methyl 3-fluoro-2-methylbenzoate 

Downstream Products

• 642408-51-3 3-fluoro-2-[({4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-phenyl}-phenyl-amino)-methyl]-benzoic acid methyl ester 
• 1407232-87-4 (S)-3-cyclohexyl-2-(4-fluoro-1-oxo-1,3-dihydro-isoindol-2-yl)-N-[1-(2-methoxy-ethyl)-1H-pyrazol-3-yl]-propionamide 
• 1407232-88-5 (S)-3-cyclohexyl-2-(4-fluoro-1-oxo-1,3-dihydro-isoindol-2-yl)-propionic acid methyl ester 
• 230301-82-3 methyl 2-(cyanomethyl)-3-fluorobenzoate 
• 230301-83-4 5-fluoro-3,4-dihydro-2H-isoquinolin-1-one 

Relevant academic research and scientific papers

Spirocyclic tetrahydroquinazolines

The invention discloses spirocyclic tetrahydroquinazolines , and particularly provide compounds represented by Formula I shown in the specification, and pharmaceutically acceptable salts and solvates thereof. In the formula, R3, A, A1, A2, A3, E, E1, E2, L, Q, Z and a structure shown in the specification are as defined in the specification,. The compounds of formula I are KRAS inhibitors and are therefore useful in the treatment of cancer and other diseases.

SPIROCYCLIC TETRAHYDROQUINAZOLINES

Provided are compounds represented by Formula I, wherein R3, A, A1, A2, A3, E, E1, E2, L, Q, Z, and (aa) are as defined in the specification, and the pharmaceutically acceptable salts and solvates thereof. Compounds of Formula (I) are KRAS inhibitors and are thus useful to treat cancer and other diseases.

OXOINDOLINE DERIVATIVES AS PROTEIN FUNCTION MODULATORS

The present invention provides chimeric compounds of formula (II) that modulate protein function, to restore protein homeostasis, including cytokine, aiolos, and/or ikaros activity, TNF-alpha activity, CKl-alpha activity and cell-cell adhesion. The invention provides methods of modulating protein-mediated diseases, such as cytokine-mediated diseases, disorders, conditions, or responses. Compositions, including in combination with other cytokine and inflammatory mediators, are provided. Methods of treatment, amelioration, or prevention of protein-mediated diseases, disorders, and conditions, such as cytokine-mediated diseases, disorders, and conditions, including inflammation, fibromyalgia, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, psoriasis, psoriatic arthritis, inflammatory bowel diseases, Crohn's disease, ulcerative colitis, uveitis, inflammatory lung diseases, chronic obstructive pulmonary disease, Alzheimer's disease, organ transplant rejection, and cancer, are provided.

ISOINDOLINONE DERIVATIVES

The present invention relates to compounds of the formula I, as well as pharmaceutically-acceptable salts thereof, pharmaceutical compositions containing said compounds and methods of using said compounds in the treatment or prophylaxis of diseases and disorders. The compounds and compositions disclosed herein are glucokinase activators useful for the treatment or prophylaxis of metabolic diseases and disorders, for example diabetes mellitus, including type II diabetes mellitus.

Tetrahydrobenzindole derivatives

Compounds containing tetrahydrobenzindole which bind to serotonin receptor and are useful in treatment or prevention of disease induced by abnormality of central peripheral serotonin controlling functions.