(+/-)-methyl N^α,N^ε-dibenzoyl-α-(E)-(2'-fluoro-2'-benzenesulfonyl)vinyllysinate

Base Information

• Chemical Name: (+/-)-methyl N^α,N^ε-dibenzoyl-α-(E)-(2'-fluoro-2'-benzenesulfonyl)vinyllysinate
• CAS No.: 714222-62-5
• Molecular Formula: C₂₉H₂₉FN₂O₆S
• Molecular Weight: 552.623

Synonyms:(+/-)-methyl N^α,N^ε-dibenzoyl-α-(E)-(2'-fluoro-2'-benzenesulfonyl)vinyllysinate

Chemical Property of (+/-)-methyl N^α,N^ε-dibenzoyl-α-(E)-(2'-fluoro-2'-benzenesulfonyl)vinyllysinate

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of (+/-)-methyl N^α,N^ε-dibenzoyl-α-(E)-(2'-fluoro-2'-benzenesulfonyl)vinyllysinate

There total 2 articles about (+/-)-methyl N^α,N^ε-dibenzoyl-α-(E)-(2'-fluoro-2'-benzenesulfonyl)vinyllysinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

phosphonic acid diethyl ester (135789-87-6,114968-97-7) + (+/-)-methyl Nα,Nε-dibenzoyl-α-formyllysinate (714222-56-7) → α,ε-N,N'-dibenzoyllysine methyl ester (133787-17-4) + (+/-)-methyl Nα,Nε-dibenzoyl-α-(E)-(2'-fluoro-2'-benzenesulfonyl)vinyllysinate (714222-62-5)

Guidance literature:

phosphonic acid diethyl ester; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.5h;

(+/-)-methyl N^α,N^ε-dibenzoyl-α-formyllysinate; In tetrahydrofuran; at -78 - 20 ℃;

DOI:10.1021/ol049422u

Reference yield:

Methyl Nα,Nε-dibenzoyl-2-vinyllysinate (74761-86-7) → (+/-)-methyl Nα,Nε-dibenzoyl-α-(E)-(2'-fluoro-2'-benzenesulfonyl)vinyllysinate (714222-62-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: ozone / CH₂Cl₂ / -78 °C

1.2: 84 percent / acetic acid; Zn / CH₂Cl₂ / Heating

2.1: LiHMDS / tetrahydrofuran / 0.5 h / -78 °C

2.2: 61 percent / tetrahydrofuran / -78 - 20 °C

With ozone; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane;

DOI:10.1021/ol049422u

upstream raw materials:

phosphonic acid diethyl ester

(+/-)-methyl N^α,N^ε-dibenzoyl-α-formyllysinate

Methyl N^α,N^ε-dibenzoyl-2-vinyllysinate

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