3-Bromo-4-methoxyaniline hydrochloride

Base Information

Chemical Name:3-Bromo-4-methoxyaniline hydrochloride
CAS No.:80523-34-8
Molecular Formula:C7H8 Br N O . Cl H
Molecular Weight:202.05
Hs Code.:2922299090
DSSTox Substance ID:DTXSID50506547
Mol file:80523-34-8.mol

Synonyms:80523-34-8;3-BROMO-4-METHOXYANILINE HYDROCHLORIDE;3-Bromo-4-methoxy aniline;3-bromo-4-methoxyaniline;hydrochloride;SCHEMBL15486482;DTXSID50506547;3-BROMO-4-METHOXYANILINE HCL;AKOS015961837;3-BROMO-4-METHOXYANILINEHYDROCHLORIDE;FT-0730916;C13363;3-Bromo-4-methoxyaniline--hydrogen chloride (1/1)

Suppliers and Price of 3-Bromo-4-methoxyaniline hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
3-Bromo-4-methoxyanilinehydrochloride 95+%
25g
$ 303.00

AHH
3-BROMO-4-METHOXYANILINE 97%
1g
$ 465.00

Total 7 raw suppliers

Chemical Property of 3-Bromo-4-methoxyaniline hydrochloride

Chemical Property:

Melting Point:247 °C (decomp)
PSA：35.25000
LogP:2.62110
Storage Temp.:Sealed in dry,Room Temperature
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:236.95560
Heavy Atom Count:11
Complexity:110

Purity/Quality:

98%Min ^*data from raw suppliers

3-Bromo-4-methoxyanilinehydrochloride 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=C(C=C(C=C1)N)Br.Cl
Uses 3-Bromo-4-methoxyaniline is an intermediate used to prepare triazole analogs of combretastatin A-4 as cytotoxic agents and inhibitors of tubulin. It is also used in the synthesis of (1,2,4-oxadiazolyl)biphenylcarbonyltetrahydrospiro[furo]indolepiperidine (SB-224289) as selective 5-HT1B receptor inverse agonist.

Technology Process of 3-Bromo-4-methoxyaniline hydrochloride

There total 1 articles about 3-Bromo-4-methoxyaniline hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5197-28-4
2-bromo-4-nitroanisole

: 80523-34-8
3-bromo-4-methoxy-phenylamine hydrochloride

Guidance literature:: 2-bromo-4-nitroanisole; With tin(II) chloride dihdyrate; In methanol; for 4h; Reflux;

With hydrogenchloride; In ethyl acetate;

Reference yield: 70.0%

: 80523-34-8
3-bromo-4-methoxy-phenylamine hydrochloride

: 75-87-6
chloral

: 130420-84-7
N-(3-Bromo-4-methoxy-phenyl)-2-[(Z)-hydroxyimino]-acetamide

Guidance literature:: With hydroxylamine hydrochloride; sodium sulfate; In water; for 0.0333333h; Heating;

Reference yield:

: 80523-34-8
3-bromo-4-methoxy-phenylamine hydrochloride

: 130420-75-6
4-bromo-5-methoxyisatin

Guidance literature:: Multi-step reaction with 2 steps

1: 70 percent / Na₂SO₄, aq. NH₂OH*HCl / H₂O / 0.03 h / Heating

2: 27 percent / conc. H₂SO₄ / 0.17 h / 80 °C

With sulfuric acid; hydroxylamine hydrochloride; sodium sulfate; In water;