3-BROMO-4-METHOXYANILINE

Base Information

• Chemical Name: 3-BROMO-4-METHOXYANILINE
• CAS No.: 80523-34-8
• Molecular Formula: C7H8 Br N O . Cl H
• Molecular Weight: 202.05
• Hs Code.: 2922299090
• Mol file: 80523-34-8.mol

Synonyms:Benzenamine,3-bromo-4-methoxy-, hydrochloride (9CI); 3-Bromo-4-methoxyaniline hydrochloride

Chemical Property of 3-BROMO-4-METHOXYANILINE

Chemical Property:

• Melting Point: 247 °C (decomp)
• PSA: 35.25000
• LogP: 2.62110
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%Min ^*data from raw suppliers

3-Bromo-4-methoxyanilinehydrochloride 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3-Bromo-4-methoxyaniline is an intermediate used to prepare triazole analogs of combretastatin A-4 as cytotoxic agents and inhibitors of tubulin. It is also used in the synthesis of (1,2,4-oxadiazolyl)biphenylcarbonyltetrahydrospiro[furo]indolepiperidine (SB-224289) as selective 5-HT1B receptor inverse agonist.

Technology Process of 3-BROMO-4-METHOXYANILINE

There total 1 articles about 3-BROMO-4-METHOXYANILINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-bromo-4-nitroanisole (5197-28-4) → 3-bromo-4-methoxy-phenylamine hydrochloride (80523-34-8)

Guidance literature:

2-bromo-4-nitroanisole; With tin(II) chloride dihdyrate; In methanol; for 4h; Reflux;

With hydrogenchloride; In ethyl acetate;

Reference yield: 70.0%

3-bromo-4-methoxy-phenylamine hydrochloride (80523-34-8) + chloral (75-87-6) → N-(3-Bromo-4-methoxy-phenyl)-2-[(Z)-hydroxyimino]-acetamide (130420-84-7)

Guidance literature:

With hydroxylamine hydrochloride; sodium sulfate; In water; for 0.0333333h; Heating;

Reference yield:

3-bromo-4-methoxy-phenylamine hydrochloride (80523-34-8) → 4-bromo-5-methoxyisatin (130420-75-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / Na₂SO₄, aq. NH₂OH*HCl / H₂O / 0.03 h / Heating

2: 27 percent / conc. H₂SO₄ / 0.17 h / 80 °C

With sulfuric acid; hydroxylamine hydrochloride; sodium sulfate; In water;

upstream raw materials:

2-bromo-4-nitroanisole

Downstream raw materials:

N-(3-Bromo-4-methoxy-phenyl)-2-[(Z)-hydroxyimino]-acetamide

6-bromo-5-methoxy-indoline-2,3-dione

4-bromo-5-methoxyisatin

6-bromo-5-methoxy-1-morpholinomethylisatin

Refernces