tert-butyl 5-(4-chloro-3-(2-methoxy-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamido)benzamido)-5-phenylpentylcarbamate

Base Information

Chemical Name:tert-butyl 5-(4-chloro-3-(2-methoxy-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamido)benzamido)-5-phenylpentylcarbamate
CAS No.:1386982-00-8
Molecular Formula:C₃₂H₃₅ClN₆O₆
Molecular Weight:635.12
Hs Code.:

Synonyms:tert-butyl 5-(4-chloro-3-(2-methoxy-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamido)benzamido)-5-phenylpentylcarbamate

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Chemical Property of tert-butyl 5-(4-chloro-3-(2-methoxy-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamido)benzamido)-5-phenylpentylcarbamate

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Technology Process of tert-butyl 5-(4-chloro-3-(2-methoxy-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamido)benzamido)-5-phenylpentylcarbamate

There total 7 articles about tert-butyl 5-(4-chloro-3-(2-methoxy-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamido)benzamido)-5-phenylpentylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.7%

: 172833-30-6
tert-butyl 5-amino-5-phenylpentylcarbamate

: 1386980-75-1
4-chloro-3-[(2-methoxy-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonyl)-amino]-benzoic acid

: 1386982-00-8
tert-butyl 5-(4-chloro-3-(2-methoxy-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamido)benzamido)-5-phenylpentylcarbamate

Guidance literature:: 4-chloro-3-[(2-methoxy-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonyl)-amino]-benzoic acid; With triethylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

tert-butyl 5-amino-5-phenylpentylcarbamate; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

Reference yield:

: 100-58-3
phenylmagnesium bromide

: 1386982-00-8
tert-butyl 5-(4-chloro-3-(2-methoxy-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamido)benzamido)-5-phenylpentylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrahydrofuran / 0.67 h / -78 °C

2.1: hydroxylamine hydrochloride; sodium acetate / ethanol; water / 5 h / Reflux

3.1: hydrogen / palladium 10% on activated carbon / methanol / 18 h

4.1: triethylamine; HATU / N,N-dimethyl-formamide / 0.5 h / 20 °C

4.2: 18 h / 20 °C

With hydroxylamine hydrochloride; hydrogen; sodium acetate; triethylamine; HATU; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 116437-42-4
(5-oxo-5-phenyl-pentyl)-carbamic acid tert-butyl ester

: 1386982-00-8
tert-butyl 5-(4-chloro-3-(2-methoxy-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamido)benzamido)-5-phenylpentylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydroxylamine hydrochloride; sodium acetate / ethanol; water / 5 h / Reflux

2.1: hydrogen / palladium 10% on activated carbon / methanol / 18 h

3.1: triethylamine; HATU / N,N-dimethyl-formamide / 0.5 h / 20 °C

3.2: 18 h / 20 °C

With hydroxylamine hydrochloride; hydrogen; sodium acetate; triethylamine; HATU; palladium 10% on activated carbon; In methanol; ethanol; water; N,N-dimethyl-formamide;