2-methyl-4-[N-methyl-N-(4-nitrophenyl)amino]-8-nitropyrazolo[1,5-a]-1,3,5-triazine

Base Information

• Chemical Name: 2-methyl-4-[N-methyl-N-(4-nitrophenyl)amino]-8-nitropyrazolo[1,5-a]-1,3,5-triazine
• CAS No.: 527704-22-9
• Molecular Formula: C₁₃H₁₁N₇O₄
• Molecular Weight: 329.275
• Mol file: 527704-22-9.mol

Synonyms:2-methyl-4-[N-methyl-N-(4-nitrophenyl)amino]-8-nitropyrazolo[1,5-a]-1,3,5-triazine

Chemical Property of 2-methyl-4-[N-methyl-N-(4-nitrophenyl)amino]-8-nitropyrazolo[1,5-a]-1,3,5-triazine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-methyl-4-[N-methyl-N-(4-nitrophenyl)amino]-8-nitropyrazolo[1,5-a]-1,3,5-triazine

There total 1 articles about 2-methyl-4-[N-methyl-N-(4-nitrophenyl)amino]-8-nitropyrazolo[1,5-a]-1,3,5-triazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2-methyl-4-(N-methyl-N-phenylamino)pyrazolo[1,5-a]-1,3,5-triazin-4-one (476468-38-9) → 2-methyl-4-[N-methyl-N-(4-nitrophenyl)amino]-8-nitropyrazolo[1,5-a]-1,3,5-triazine (527704-22-9)

Guidance literature:

With nitric acid; at 0 ℃; for 0.166667h;

DOI:10.1016/S0040-4039(02)02661-8

Reference yield: 68.0%

2-methyl-4-[N-methyl-N-(4-nitrophenyl)amino]-8-nitropyrazolo[1,5-a]-1,3,5-triazine (527704-22-9) → 8-amino-4-[N-(4-aminophenyl)-N-methylamino]pyrazolo[1,5-a]-1,3,5-triazine (527704-23-0)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; for 2h;

DOI:10.1016/S0040-4039(02)02661-8

Reference yield:

2-methyl-4-[N-methyl-N-(4-nitrophenyl)amino]-8-nitropyrazolo[1,5-a]-1,3,5-triazine (527704-22-9) → N-{2-methyl-4-[methyl-(4-phenylacetylamino-phenyl)-amino]-pyrazolo[1,5-a][1,3,5]triazin-8-yl}-2-phenyl-acetamide

Guidance literature:

Multi-step reaction with 2 steps

1: 68 percent / H₂ / Pd/C / methanol / 2 h / 20 °C

2: triethylamine / CH₂Cl₂ / 0 °C

With hydrogen; triethylamine; palladium on activated charcoal; In methanol; dichloromethane;

DOI:10.1016/S0040-4039(02)02661-8

upstream raw materials:

2-methyl-4-(N-methyl-N-phenylamino)pyrazolo[1,5-a]-1,3,5-triazin-4-one

Downstream raw materials:

8-amino-4-[N-(4-aminophenyl)-N-methylamino]pyrazolo[1,5-a]-1,3,5-triazine

8-acetamido-4-[N-(4-acetamidophenyl)-N-methylamino]-2-methylpyrazolo[1,5-a]-1,3,5-triazine