N-{3-cyano-3-[(4-methyl-piperazin-1-yl)carbonyl]cyclohexyl}-6-(3-fluorophenyl)nicotinamide

Base Information

Chemical Name:N-{3-cyano-3-[(4-methyl-piperazin-1-yl)carbonyl]cyclohexyl}-6-(3-fluorophenyl)nicotinamide
CAS No.:1202410-58-9
Molecular Formula:C₂₅H₂₈FN₅O₂
Molecular Weight:449.528
Hs Code.:

Synonyms:N-{3-cyano-3-[(4-methyl-piperazin-1-yl)carbonyl]cyclohexyl}-6-(3-fluorophenyl)nicotinamide

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Chemical Property of N-{3-cyano-3-[(4-methyl-piperazin-1-yl)carbonyl]cyclohexyl}-6-(3-fluorophenyl)nicotinamide

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Technology Process of N-{3-cyano-3-[(4-methyl-piperazin-1-yl)carbonyl]cyclohexyl}-6-(3-fluorophenyl)nicotinamide

There total 10 articles about N-{3-cyano-3-[(4-methyl-piperazin-1-yl)carbonyl]cyclohexyl}-6-(3-fluorophenyl)nicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 582325-22-2
6-(3-fluorophenyl)-3-pyridinecarboxylic acid

: 1202411-81-1
3-amino-1-[(4-methylpiperazin-1-yl)carbonyl]cyclohexanecarbonitrile

: 1202410-58-9
N-{3-cyano-3-[(4-methyl-piperazin-1-yl)carbonyl]cyclohexyl}-6-(3-fluorophenyl)nicotinamide

Guidance literature:: With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; N,N-dimethyl-formamide; at 0 - 20 ℃; for 49h;

Reference yield:

: 5326-23-8
6-Chloro-3-pyridinecarboxylic acid

: 1202410-58-9
N-{3-cyano-3-[(4-methyl-piperazin-1-yl)carbonyl]cyclohexyl}-6-(3-fluorophenyl)nicotinamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrabutylammomium bromide; potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; toluene / 20 h / Reflux

1.2: pH 3

2.1: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane; N,N-dimethyl-formamide / 49 h / 0 - 20 °C

With 1-hydroxy-7-aza-benzotriazole; tetrabutylammomium bromide; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1202411-77-5
N,N-dibenzyl-1,5-dichloropentan-2-amine

: 1202410-58-9
N-{3-cyano-3-[(4-methyl-piperazin-1-yl)carbonyl]cyclohexyl}-6-(3-fluorophenyl)nicotinamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 16 h / 79 °C

2.1: lithium hydroxide monohydrate; water / tetrahydrofuran / 16 h / 52 °C

2.2: pH 6

3.1: HATU / N,N-dimethyl-formamide / 48.83 h / 0 - 20 °C

4.1: hydrogen / palladium 10% on activated carbon / ethanol / 48 h / 20 °C / 760.05 Torr

5.1: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane; N,N-dimethyl-formamide / 49 h / 0 - 20 °C

With 1-hydroxy-7-aza-benzotriazole; lithium hydroxide monohydrate; water; hydrogen; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; HATU; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;