582325-22-2

Usage

Uses

Used in Medicinal Chemistry:
6-(3-Fluorophenyl)-nicotinic acid is used as a chemical intermediate for the synthesis of various pharmaceuticals and biologically active compounds. Its unique structure allows it to interact with specific biological targets, potentially modulating their functions and leading to the development of new therapeutic agents.
Used in Drug Discovery:
In the pharmaceutical industry, 6-(3-Fluorophenyl)-nicotinic acid is utilized as a lead compound in drug discovery efforts. Its ability to bind and influence biological targets makes it a valuable tool for identifying novel therapeutic agents with potential applications in treating various diseases and conditions.
Used in Research and Development:
6-(3-Fluorophenyl)-nicotinic acid is employed as a research compound in academic and industrial laboratories. Its unique properties and potential interactions with biological systems make it an interesting subject for further investigation, contributing to the advancement of knowledge in medicinal chemistry and related fields.

Upstream product

• 5326-23-8 6-Chloro-3-pyridinecarboxylic acid 
• 768-35-4 3-fluorophenylboronic acid 

Downstream Products

• 1000812-77-0 6-(3-fluorophenyl)-3-pyridinecarbonyl chloride 
• 1033843-48-9 Benzyl 4-({[6-(3-fluorophenyl)pyridin-3-yl]carbonyl}amino)piperidine-1-carboxylate 
• 1033844-25-5 tert-butyl 3-(2-(3-fluorophenyl)nicotinamido)azetidine-1-carboxylate 
• 1033844-24-4 tert-butyl 4-(2-(3-fluorophenyl)nicotinamido)piperidine-1-carboxylate 
• 1033836-12-2 6-(3-Fluorophenyl)-N-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)nicotinamide 
• 1033837-05-6 6-(3-fluoro-phenyl)-N-[1-(1-methyl-1H-tetrazol-5-yl)-piperidin-4-yl]-nicotinamide 
• 1033844-79-9 tert-butyl (1R,5S,6s)-6-({[6-(3-fluorophenyl)pyridine-3-yl]carbonyl}amino)3-azabicyclo[3.1.0]hexane-3-carboxylate 
• 1033844-05-1 N-[1-(7,8-Dihydro-5H-pyrano[4,3-d]pyrimidin-2-yl)piperidin-4-yl]-6-(3-fluorophenyl)nicotinamide 
• 582324-64-9 C₂₁H₁₄FN₃O 
• 1202409-50-4 6-(3-fluorophenyl)-N-(4-hydroxy-piperidin-1ylmethylcyclohexyl)nicotinamide 

Relevant academic research and scientific papers

NICOTINAMIDE DERIVATIVES

The present invention relates to compounds of the formula (I) and pharmaceutically acceptable salts and solvates thereof, wherein the substituents are defined herein, to compositions containing such compounds and to the uses of such compounds for the trea

Design and synthesis of 6-phenylnicotinamide derivatives as antagonists of TRPV1

6-Phenylnicotinamide (2) was previously identified as a potent TRPV1 antagonist with activity in an in vivo model of inflammatory pain. Optimization of this lead through modification of both the biaryl and heteroaryl components has resulted in the discovery of 6-(4-fluorophenyl)-2-methyl-N-(2-methylbenzothiazol-5-yl)nicotinamide (32; SB-782443) which possesses an excellent overall profile and has been progressed into pre-clinical development.

Nicotinamide Derivatives

The present invention relates to compounds of formula (I) and pharmaceutically acceptable salts and solvates thereof, wherein the substituents are as defined herein, compositions containing such compounds and the uses of such compounds for the treatment o