(R,E)-2-(4-(5-(1,2-dithiolan-3-yl)pentanoyl)piperazin-1-yl)ethyl 3-(3-acetoxy-4-methoxyphenyl)acrylate

Base Information

Chemical Name:(R,E)-2-(4-(5-(1,2-dithiolan-3-yl)pentanoyl)piperazin-1-yl)ethyl 3-(3-acetoxy-4-methoxyphenyl)acrylate
CAS No.:1451180-84-9
Molecular Formula:C₂₆H₃₆N₂O₆S₂
Molecular Weight:536.714
Hs Code.:

Synonyms:(R,E)-2-(4-(5-(1,2-dithiolan-3-yl)pentanoyl)piperazin-1-yl)ethyl 3-(3-acetoxy-4-methoxyphenyl)acrylate

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Chemical Property of (R,E)-2-(4-(5-(1,2-dithiolan-3-yl)pentanoyl)piperazin-1-yl)ethyl 3-(3-acetoxy-4-methoxyphenyl)acrylate

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Technology Process of (R,E)-2-(4-(5-(1,2-dithiolan-3-yl)pentanoyl)piperazin-1-yl)ethyl 3-(3-acetoxy-4-methoxyphenyl)acrylate

There total 3 articles about (R,E)-2-(4-(5-(1,2-dithiolan-3-yl)pentanoyl)piperazin-1-yl)ethyl 3-(3-acetoxy-4-methoxyphenyl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1234345-57-3
3-acetoxy-4-methoxycinnamoyl chloride

: 1451180-79-2
C₁₄H₂₆N₂O₂S₂

: 1451180-84-9
(R,E)-2-(4-(5-(1,2-dithiolan-3-yl)pentanoyl)piperazin-1-yl)ethyl 3-(3-acetoxy-4-methoxyphenyl)acrylate

Guidance literature:: C₁₄H₂₆N₂O₂S₂; With dmap; In dichloromethane; for 0.25h; Inert atmosphere;

3-acetoxy-4-methoxycinnamoyl chloride; In dichloromethane; for 3h; Inert atmosphere; Cooling with ice;
DOI:10.5012/bkcs.2013.34.4.1025

Reference yield:

: 1115175-97-7
2,5-dioxopyrrolidin-1-yl 5-(1,2-dithiolan-3-yl)pentanoate

: 1451180-84-9
(R,E)-2-(4-(5-(1,2-dithiolan-3-yl)pentanoyl)piperazin-1-yl)ethyl 3-(3-acetoxy-4-methoxyphenyl)acrylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: Inert atmosphere

2.1: dmap / dichloromethane / 0.25 h / Inert atmosphere

2.2: 3 h / Inert atmosphere; Cooling with ice

With dmap; In dichloromethane;
DOI:10.5012/bkcs.2013.34.4.1025

Reference yield:

: 1200-22-2
(R)-1,2-dithiolane-3-pentanoic acid

: 1451180-84-9
(R,E)-2-(4-(5-(1,2-dithiolan-3-yl)pentanoyl)piperazin-1-yl)ethyl 3-(3-acetoxy-4-methoxyphenyl)acrylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / Inert atmosphere

2.1: Inert atmosphere

3.1: dmap / dichloromethane / 0.25 h / Inert atmosphere

3.2: 3 h / Inert atmosphere; Cooling with ice

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;
DOI:10.5012/bkcs.2013.34.4.1025