7-BROMO-4-FLUOROINDOLE

Base Information

• Chemical Name: 7-BROMO-4-FLUOROINDOLE
• CAS No.: 292636-09-0
• Molecular Formula: C8H5BrFN
• Molecular Weight: 214.037
• Hs Code.: 2933990090
• Mol file: 292636-09-0.mol

Synonyms:4-Fluoro-7-bromoindole;7-Bromo-4-fluoroindole;7-Bromo-4-fluoro-1H-indole;1H-indole, 7-bromo-4-fluoro-;

Chemical Property of 7-BROMO-4-FLUOROINDOLE

Chemical Property:

• Vapor Pressure: 0.000874mmHg at 25°C
• Refractive Index: 1.68
• Boiling Point: 314.2 °C at 760 mmHg
• PKA: 14.73±0.30(Predicted)
• Flash Point: 143.8 °C
• PSA: 15.79000
• Density: 1.75 g/cm³
• LogP: 3.06950
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Sensitive.: Light Sensitive

Purity/Quality:

99%, ^*data from raw suppliers

7-Bromo-4-fluoro-1H-indole ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-BROMO-4-FLUOROINDOLE

There total 4 articles about 7-BROMO-4-FLUOROINDOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

2-bromo-5-fluoronitrobenzene (446-09-3) → 7-bromo-4-fluoro-1H-indole (292636-09-0)

Guidance literature:

With vinyl magnesium bromide; In tetrahydrofuran; 1,2-dimethoxyethane; at -78 ℃; for 4h; Inert atmosphere;

Reference yield: 52.0%

2-bromo-5-fluoronitrobenzene (446-09-3) + vinyl magnesium bromide (1826-67-1) → 7-bromo-4-fluoro-1H-indole (292636-09-0)

Guidance literature:

In tetrahydrofuran; at -40 ℃; for 1.5h;

DOI:10.1002/ejoc.200600118

Reference yield: 38.0%

→ 7-bromo-4-fluoro-1H-indole (292636-09-0)

Guidance literature:

upstream raw materials:

2-bromo-5-fluoronitrobenzene

vinyl magnesium bromide

1-Bromo-4-fluorobenzene

Downstream raw materials:

4-fluoroindole-7-carboxylic acid

4-fluoro-1H-indole-7-carbonitrile

1-(4-Benzoyl-piperazin-1-yl)-2-(4-fluoro-7-[1,2,4]oxadiazol-3-yl-1H-indol-3-yl)-ethane-1,2-dione

1-(4-Benzoyl-piperazin-1-yl)-2-[4-fluoro-7-(2H-tetrazol-5-yl)-1H-indol-3-yl]-ethane-1,2-dione

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