N-methyl-N-(o-nitrobenzenesulfonyl)-L-aspartic acid β-t-butyl ester methyl ester

Base Information

• Chemical Name: N-methyl-N-(o-nitrobenzenesulfonyl)-L-aspartic acid β-t-butyl ester methyl ester
• CAS No.: 856865-71-9
• Molecular Formula: C₁₆H₂₂N₂O₈S
• Molecular Weight: 402.425

Synonyms:N-methyl-N-(o-nitrobenzenesulfonyl)-L-aspartic acid β-t-butyl ester methyl ester

Chemical Property of N-methyl-N-(o-nitrobenzenesulfonyl)-L-aspartic acid β-t-butyl ester methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-methyl-N-(o-nitrobenzenesulfonyl)-L-aspartic acid β-t-butyl ester methyl ester

There total 3 articles about N-methyl-N-(o-nitrobenzenesulfonyl)-L-aspartic acid β-t-butyl ester methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

N-(o-nitrobenzenesulfonyl)-L-aspartic acid β-t-butyl ester methyl ester (856865-56-0) + dimethyl sulfate (77-78-1) → N-methyl-N-(o-nitrobenzenesulfonyl)-L-aspartic acid β-t-butyl ester methyl ester (856865-71-9)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In N,N-dimethyl-formamide; at 0 ℃; for 0.25h;

DOI:10.1021/jo050477z

Reference yield:

2-Nitrobenzenesulfonyl chloride (1694-92-4) → N-methyl-N-(o-nitrobenzenesulfonyl)-L-aspartic acid β-t-butyl ester methyl ester (856865-71-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 86 percent / triethylamine / CH₂Cl₂

2: 96 percent / 1,8-diazabicyclo[5.4.0]undec-7-ene / dimethylformamide / 0.25 h / 0 °C

With 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jo050477z

Reference yield:

4-tert-butyl 1-methyl L-aspartate hydrochloride (2673-19-0,63329-02-2) → N-methyl-N-(o-nitrobenzenesulfonyl)-L-aspartic acid β-t-butyl ester methyl ester (856865-71-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 86 percent / triethylamine / CH₂Cl₂

2: 96 percent / 1,8-diazabicyclo[5.4.0]undec-7-ene / dimethylformamide / 0.25 h / 0 °C

With 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jo050477z

upstream raw materials:

N-(o-nitrobenzenesulfonyl)-L-aspartic acid β-t-butyl ester methyl ester

dimethyl sulfate

2-Nitrobenzenesulfonyl chloride

4-tert-butyl 1-methyl L-aspartate hydrochloride

Downstream raw materials:

N-α-methyl-N-α-(o-nitrobenzenesulfonyl)-L-aspartic acid β-t-butyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 856865-71-9 N-methyl-N-(o-nitrobenzenesulfonyl)-L-aspartic acid β-t-butyl ester methyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send