N-(o-nitrobenzenesulfonyl)-L-aspartic acid β-t-butyl ester methyl ester

Base Information

Chemical Name:N-(o-nitrobenzenesulfonyl)-L-aspartic acid β-t-butyl ester methyl ester
CAS No.:856865-56-0
Molecular Formula:C₁₅H₂₀N₂O₈S
Molecular Weight:388.398
Hs Code.:

Synonyms:N-(o-nitrobenzenesulfonyl)-L-aspartic acid β-t-butyl ester methyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(o-nitrobenzenesulfonyl)-L-aspartic acid β-t-butyl ester methyl ester

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Technology Process of N-(o-nitrobenzenesulfonyl)-L-aspartic acid β-t-butyl ester methyl ester

There total 2 articles about N-(o-nitrobenzenesulfonyl)-L-aspartic acid β-t-butyl ester methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1694-92-4
2-Nitrobenzenesulfonyl chloride

: 2673-19-0,63329-02-2
4-tert-butyl 1-methyl L-aspartate hydrochloride

: 856865-56-0
N-(o-nitrobenzenesulfonyl)-L-aspartic acid β-t-butyl ester methyl ester

Guidance literature:: With triethylamine; In dichloromethane;
DOI:10.1021/jo050477z

Reference yield:

: 67-56-1
methanol

: 2‐chlorotrityl chloride resin

: 71989-14-5
Fmoc-(tBu)Asp-OH

: 1694-92-4
2-Nitrobenzenesulfonyl chloride

: 856865-56-0
N-(o-nitrobenzenesulfonyl)-L-aspartic acid β-t-butyl ester methyl ester

: Ns-Asp(O-tBu)-OH

Guidance literature:: 2‐chlorotrityl chloride resin; Fmoc-(tBu)Asp-OH; With dmap; benzotriazol-1-ol; diisopropyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide; at 0.24 ℃; for 16h; Wang resin

With piperidine; In N,N-dimethyl-formamide; at 0.24 ℃; for 0.25h;

methanol; 2-Nitrobenzenesulfonyl chloride; Further stages;
DOI:10.1021/acs.joc.0c00599