2-((2R,3R,4R,5R)-3,4-bis(benzyloxy)-5-((benzyloxy)methyl)pyrrolidin-2-yl)-N-methylacetamide

Base Information

Chemical Name:2-((2R,3R,4R,5R)-3,4-bis(benzyloxy)-5-((benzyloxy)methyl)pyrrolidin-2-yl)-N-methylacetamide
CAS No.:1567688-10-1
Molecular Formula:C₂₉H₃₄N₂O₄
Molecular Weight:474.6
Hs Code.:

Synonyms:2-((2R,3R,4R,5R)-3,4-bis(benzyloxy)-5-((benzyloxy)methyl)pyrrolidin-2-yl)-N-methylacetamide

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Chemical Property of 2-((2R,3R,4R,5R)-3,4-bis(benzyloxy)-5-((benzyloxy)methyl)pyrrolidin-2-yl)-N-methylacetamide

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Technology Process of 2-((2R,3R,4R,5R)-3,4-bis(benzyloxy)-5-((benzyloxy)methyl)pyrrolidin-2-yl)-N-methylacetamide

There total 7 articles about 2-((2R,3R,4R,5R)-3,4-bis(benzyloxy)-5-((benzyloxy)methyl)pyrrolidin-2-yl)-N-methylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1567688-08-7
(2R,3R,4R,5R)-tert-butyl 3,4-bis(benzyloxy)-2-((benzyloxy)methyl)-5-(2-(methylamino)-2-oxoethyl)pyrrolidine-1-carboxylate

: 1567688-10-1
2-((2R,3R,4R,5R)-3,4-bis(benzyloxy)-5-((benzyloxy)methyl)pyrrolidin-2-yl)-N-methylacetamide

Guidance literature:: With hydrogenchloride; In methanol; water; ethyl acetate; for 2h;

Reference yield:

: 1105054-59-8
(2R,3R,4R,5R)-2-allyl-3,4-bis(benzyloxy)-5-((benzyloxy)methyl)pyrrolidin-1-ol

: 1567688-10-1
2-((2R,3R,4R,5R)-3,4-bis(benzyloxy)-5-((benzyloxy)methyl)pyrrolidin-2-yl)-N-methylacetamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: zinc / methanol; acetic acid / 1 h / Reflux

1.2: 16 h / 20 °C

2.1: 4-methylmorpholine N-oxide; osmium(VIII) oxide / water; acetone / 16 h / 20 °C

3.1: sodium periodate / tetrahydrofuran / 3 h / 20 °C / Alkaline conditions

4.1: 2-methyl-but-2-ene; sodium chlorite; sodium dihydrogenphosphate / chloroform-d1; tert-butyl alcohol / 3 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 48 h / 20 °C

6.1: hydrogenchloride / methanol; water; ethyl acetate / 2 h

With hydrogenchloride; sodium chlorite; sodium periodate; sodium dihydrogenphosphate; osmium(VIII) oxide; 2-methyl-but-2-ene; 4-methylmorpholine N-oxide; N-ethyl-N,N-diisopropylamine; HATU; zinc; In tetrahydrofuran; methanol; chloroform-d1; water; acetic acid; ethyl acetate; N,N-dimethyl-formamide; acetone; tert-butyl alcohol;

Reference yield:

: 1567688-03-2
(2R,3R,4R,5R)-tert-butyl 3,4-bis(benzyloxy)-2-((benzyloxy)methyl)-5-(2,3-dihydroxypropyl)pyrrolidine-1-carboxylate

: 1567688-10-1
2-((2R,3R,4R,5R)-3,4-bis(benzyloxy)-5-((benzyloxy)methyl)pyrrolidin-2-yl)-N-methylacetamide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium periodate / tetrahydrofuran / 3 h / 20 °C / Alkaline conditions

2: 2-methyl-but-2-ene; sodium chlorite; sodium dihydrogenphosphate / chloroform-d1; tert-butyl alcohol / 3 h / 20 °C

3: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 48 h / 20 °C

4: hydrogenchloride / methanol; water; ethyl acetate / 2 h

With hydrogenchloride; sodium chlorite; sodium periodate; sodium dihydrogenphosphate; 2-methyl-but-2-ene; N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; methanol; chloroform-d1; water; ethyl acetate; N,N-dimethyl-formamide; tert-butyl alcohol;