Technology Process of (2R,3R,4R,5R)-tert-butyl 3,4-bis(benzyloxy)-2-((benzyloxy)methyl)-5-(2-(methylamino)-2-oxoethyl)pyrrolidine-1-carboxylate
There total 6 articles about (2R,3R,4R,5R)-tert-butyl 3,4-bis(benzyloxy)-2-((benzyloxy)methyl)-5-(2-(methylamino)-2-oxoethyl)pyrrolidine-1-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
N-ethyl-N,N-diisopropylamine; HATU;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 48h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: zinc / methanol; acetic acid / 1 h / Reflux
1.2: 16 h / 20 °C
2.1: 4-methylmorpholine N-oxide; osmium(VIII) oxide / water; acetone / 16 h / 20 °C
3.1: sodium periodate / tetrahydrofuran / 3 h / 20 °C / Alkaline conditions
4.1: 2-methyl-but-2-ene; sodium chlorite; sodium dihydrogenphosphate / chloroform-d1; tert-butyl alcohol / 3 h / 20 °C
5.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 48 h / 20 °C
With
sodium chlorite; sodium periodate; sodium dihydrogenphosphate; osmium(VIII) oxide; 2-methyl-but-2-ene; 4-methylmorpholine N-oxide; N-ethyl-N,N-diisopropylamine; HATU; zinc;
In
tetrahydrofuran; methanol; chloroform-d1; water; acetic acid; N,N-dimethyl-formamide; acetone; tert-butyl alcohol;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: sodium periodate / tetrahydrofuran / 3 h / 20 °C / Alkaline conditions
2: 2-methyl-but-2-ene; sodium chlorite; sodium dihydrogenphosphate / chloroform-d1; tert-butyl alcohol / 3 h / 20 °C
3: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 48 h / 20 °C
With
sodium chlorite; sodium periodate; sodium dihydrogenphosphate; 2-methyl-but-2-ene; N-ethyl-N,N-diisopropylamine; HATU;
In
tetrahydrofuran; chloroform-d1; N,N-dimethyl-formamide; tert-butyl alcohol;