Technology Process of 4-[(5S)-5,6,7,8-Tetrahydro-6β,7α-dimethylnaphtho[2,3-d]-1,3-dioxol-5α-yl]phenol
There total 4 articles about 4-[(5S)-5,6,7,8-Tetrahydro-6β,7α-dimethylnaphtho[2,3-d]-1,3-dioxol-5α-yl]phenol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
perchloric acid; hydrogen;
palladium on activated charcoal;
In
ethyl acetate;
for 18h;
under 3800 Torr;
Ambient temperature;
DOI:10.1016/S0040-4020(01)82448-0
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 97.5 percent / 4-dimethylaminopyridine / pyridine / 1) <5 deg C, 2.5 h; 2) +5 deg C, 2 h
2: 67.9 percent / LiAlH4 / tetrahydrofuran / 1) 30 min, RT; 2) 4 h, reflux
3: 82.6 percent / H2, HClO4 / Pd/C / ethyl acetate / 18 h / 3800 Torr / Ambient temperature
With
dmap; lithium aluminium tetrahydride; perchloric acid; hydrogen;
palladium on activated charcoal;
In
tetrahydrofuran; pyridine; ethyl acetate;
DOI:10.1016/S0040-4020(01)82448-0
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 88.1 percent / LiAlH4 / tetrahydrofuran / 3 h / Ambient temperature
2: 97.5 percent / 4-dimethylaminopyridine / pyridine / 1) <5 deg C, 2.5 h; 2) +5 deg C, 2 h
3: 67.9 percent / LiAlH4 / tetrahydrofuran / 1) 30 min, RT; 2) 4 h, reflux
4: 82.6 percent / H2, HClO4 / Pd/C / ethyl acetate / 18 h / 3800 Torr / Ambient temperature
With
dmap; lithium aluminium tetrahydride; perchloric acid; hydrogen;
palladium on activated charcoal;
In
tetrahydrofuran; pyridine; ethyl acetate;
DOI:10.1016/S0040-4020(01)82448-0
