(benzyloxy-4 phenyl)-1-r bis-methanesulfonyloxymethyl l-2-t,3-c methylenedioxy-6,7 tetrahydro-1,2,3,4 naphtalene

Base Information

• Chemical Name: (benzyloxy-4 phenyl)-1-r bis-methanesulfonyloxymethyl l-2-t,3-c methylenedioxy-6,7 tetrahydro-1,2,3,4 naphtalene
• CAS No.: 72011-48-4
• Molecular Formula: C₂₈H₃₀O₉S₂
• Molecular Weight: 574.673
• Mol file: 72011-48-4.mol

Synonyms:(benzyloxy-4 phenyl)-1-r bis-methanesulfonyloxymethyl l-2-t,3-c methylenedioxy-6,7 tetrahydro-1,2,3,4 naphtalene

Chemical Property of (benzyloxy-4 phenyl)-1-r bis-methanesulfonyloxymethyl l-2-t,3-c methylenedioxy-6,7 tetrahydro-1,2,3,4 naphtalene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (benzyloxy-4 phenyl)-1-r bis-methanesulfonyloxymethyl l-2-t,3-c methylenedioxy-6,7 tetrahydro-1,2,3,4 naphtalene

There total 2 articles about (benzyloxy-4 phenyl)-1-r bis-methanesulfonyloxymethyl l-2-t,3-c methylenedioxy-6,7 tetrahydro-1,2,3,4 naphtalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.5%

methanesulfonyl chloride (124-63-0) + (benzyloxy-4 phenyl)-1-r bis-hydroxymethyl l-2-t,3c methylenedioxy-6,7 tetrahydro-1,2,3,4 naphtalene (72011-47-3,73610-98-7) → (benzyloxy-4 phenyl)-1-r bis-methanesulfonyloxymethyl l-2-t,3-c methylenedioxy-6,7 tetrahydro-1,2,3,4 naphtalene (72011-48-4)

Guidance literature:

With dmap; In pyridine; 1) <5 deg C, 2.5 h; 2) +5 deg C, 2 h;

DOI:10.1016/S0040-4020(01)82448-0

Reference yield:

(benzyloxy-4 phenyl)-9 methylenedioxy-6,7 tetrahydro-3a,4,9,9a naphto<2,3-c> furannone-1 (3H) (72011-46-2,73650-05-2) → (benzyloxy-4 phenyl)-1-r bis-methanesulfonyloxymethyl l-2-t,3-c methylenedioxy-6,7 tetrahydro-1,2,3,4 naphtalene (72011-48-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 88.1 percent / LiAlH₄ / tetrahydrofuran / 3 h / Ambient temperature

2: 97.5 percent / 4-dimethylaminopyridine / pyridine / 1) <5 deg C, 2.5 h; 2) +5 deg C, 2 h

With dmap; lithium aluminium tetrahydride; In tetrahydrofuran; pyridine;

DOI:10.1016/S0040-4020(01)82448-0

Reference yield: 67.9%

(benzyloxy-4 phenyl)-1-r bis-methanesulfonyloxymethyl l-2-t,3-c methylenedioxy-6,7 tetrahydro-1,2,3,4 naphtalene (72011-48-4) → (+/-)-O-benzyl attenol (72011-49-5,73650-06-3)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; 1) 30 min, RT; 2) 4 h, reflux;

DOI:10.1016/S0040-4020(01)82448-0

upstream raw materials:

methanesulfonyl chloride

(benzyloxy-4 phenyl)-1-r bis-hydroxymethyl l-2-t,3c methylenedioxy-6,7 tetrahydro-1,2,3,4 naphtalene

(benzyloxy-4 phenyl)-9 methylenedioxy-6,7 tetrahydro-3a,4,9,9a naphto<2,3-c> furannone-1 (3H)

Downstream raw materials:

(+/-)-O-benzyl attenol

(+/-)-attenuol