HEXADECANOIC-9,9-D2 ACID

Base Information

• Chemical Name: HEXADECANOIC-9,9-D2 ACID
• CAS No.: 272442-14-5
• Molecular Formula: C₁₆H₃₂O₂
• Molecular Weight: 261.389
• Mol file: 272442-14-5.mol

Synonyms:9,9-d2-Palmiticacid

Chemical Property of HEXADECANOIC-9,9-D2 ACID

Chemical Property:

• PSA: 37.30000
• LogP: 5.55230

Purity/Quality:

99% ^*data from raw suppliers

HexadecanoicAcid-9,9-d2 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Hexadecanoic-9,9-d2 Acid (CAS# 272442-14-5) is a useful isotopically labeled research compound.

Technology Process of HEXADECANOIC-9,9-D2 ACID

There total 75 articles about HEXADECANOIC-9,9-D2 ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1-hexadecylcarboxylic acid (57-10-3) → palmitic acid-d31 (39756-30-4,272442-14-5,285979-77-3,358730-99-1,78387-70-9,1219802-61-5)

Guidance literature:

1-hexadecylcarboxylic acid; With d8-isopropanol; 10% Pt/activated carbon; water-d2; at 120 ℃; for 24h;

With water; sodium hydroxide; at 70 ℃; for 24h; Reagent/catalyst;

DOI:10.1002/adsc.201600363

Reference yield: 69.0%

(R)-[9,9,10,10,11-2H5]-1-hexadecanol (790696-08-1) → (R)-[9,9,10,10,11-2H5]-hexadecanoic acid (272442-14-5,78387-70-9)

Guidance literature:

With dipyridinium dichromate; In N,N-dimethyl-formamide; for 72h;

DOI:10.1021/jo049320h

Reference yield: 65.0%

(S)-[9,9,10,10,11-2H5]-1-hexadecanol (790696-09-2) → (S)-[9,9,10,10,11-2H5]-hexadecanoic acid (272442-14-5,78387-70-9)

Guidance literature:

With dipyridinium dichromate; In N,N-dimethyl-formamide; for 72h;

DOI:10.1021/jo049320h

upstream raw materials:

1-hexadecylcarboxylic acid

azelaic acid

methyl 9-chloro-9-oxononanoate

azelaic monomethyl ester

Downstream raw materials:

tripalmitin-d₉₃

1-hexadecyl-d33-ol

d33-hexadecanethiol

[D₃₃]-hexadecyl bromide

Refernces

• 1、 Froessl, Christian,Boland, Wilhelm. "Synthesis of Deuterium Labelled (11S,12R)- and (11R,12S)--Palmitic Acids; a Facile Route to Highly Labelled Fatty Acids". . p. 6613 - 6618. Retrieved 1993.
• 2、 Liu, Lan,Michelsen, Klaus,Kitova, Elena N.,Schnier, Paul D.,Brown, Alex,Klassen, John S.. "Deuterium kinetic isotope effects on the dissociation of a protein-fatty acid complex in the gas phase". scheme or table. p. 5931 - 5937. Retrieved 2012/05/07.