{3-[1-(3,4-Dichloro-phenyl)-meth-(E)-ylidene]-6-fluoro-2-oxo-2,3-dihydro-indol-1-yl}-acetic acid benzyl ester

Base Information

Chemical Name:{3-[1-(3,4-Dichloro-phenyl)-meth-(E)-ylidene]-6-fluoro-2-oxo-2,3-dihydro-indol-1-yl}-acetic acid benzyl ester
CAS No.:114727-50-3
Molecular Formula:C₂₄H₁₆Cl₂FNO₃
Molecular Weight:456.3
Hs Code.:

Synonyms:{3-[1-(3,4-Dichloro-phenyl)-meth-(E)-ylidene]-6-fluoro-2-oxo-2,3-dihydro-indol-1-yl}-acetic acid benzyl ester

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Chemical Property of {3-[1-(3,4-Dichloro-phenyl)-meth-(E)-ylidene]-6-fluoro-2-oxo-2,3-dihydro-indol-1-yl}-acetic acid benzyl ester

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Technology Process of {3-[1-(3,4-Dichloro-phenyl)-meth-(E)-ylidene]-6-fluoro-2-oxo-2,3-dihydro-indol-1-yl}-acetic acid benzyl ester

There total 3 articles about {3-[1-(3,4-Dichloro-phenyl)-meth-(E)-ylidene]-6-fluoro-2-oxo-2,3-dihydro-indol-1-yl}-acetic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 56341-39-0
6-fluoro-2-oxindole

: 114727-50-3
{3-[1-(3,4-Dichloro-phenyl)-meth-(E)-ylidene]-6-fluoro-2-oxo-2,3-dihydro-indol-1-yl}-acetic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 84 percent / pyrrolidine / methanol / 0.25 h / Heating

2: 1.) NaH / 1.) DMF, 25 deg C, 15 min, 2.) DMF, 30 min

With pyrrolidine; sodium hydride; In methanol;
DOI:10.1016/0223-5234(92)90112-E

Reference yield:

: 6287-38-3
3,4-dichlorobenzaldehyde

: 114727-50-3
{3-[1-(3,4-Dichloro-phenyl)-meth-(E)-ylidene]-6-fluoro-2-oxo-2,3-dihydro-indol-1-yl}-acetic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 84 percent / pyrrolidine / methanol / 0.25 h / Heating

2: 1.) NaH / 1.) DMF, 25 deg C, 15 min, 2.) DMF, 30 min

With pyrrolidine; sodium hydride; In methanol;
DOI:10.1016/0223-5234(92)90112-E

Reference yield:

: 114727-45-6
3-(3,4-dichlorobenzylidene)-6-fluoro-oxindole hemihydrate

: 5437-45-6
Benzyl bromoacetate

: 114727-50-3
{3-[1-(3,4-Dichloro-phenyl)-meth-(E)-ylidene]-6-fluoro-2-oxo-2,3-dihydro-indol-1-yl}-acetic acid benzyl ester

Guidance literature:: With sodium hydride; Yield given. Multistep reaction; 1.) DMF, 25 deg C, 15 min, 2.) DMF, 30 min;
DOI:10.1016/0223-5234(92)90112-E