3-((4-((4-(3-(3-(tert-butyl)-1-(6-methoxypyridin-3-yl)-1H-pyrazol-5-yl)ureido)naphthalen-1-yl)oxy)pyrimidin-2-yl)amino)phenyl methanesulfonate

Base Information

Chemical Name:3-((4-((4-(3-(3-(tert-butyl)-1-(6-methoxypyridin-3-yl)-1H-pyrazol-5-yl)ureido)naphthalen-1-yl)oxy)pyrimidin-2-yl)amino)phenyl methanesulfonate
CAS No.:1610449-25-6
Molecular Formula:C₃₅H₃₄N₈O₆S
Molecular Weight:694.771
Hs Code.:

Synonyms:3-((4-((4-(3-(3-(tert-butyl)-1-(6-methoxypyridin-3-yl)-1H-pyrazol-5-yl)ureido)naphthalen-1-yl)oxy)pyrimidin-2-yl)amino)phenyl methanesulfonate

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Chemical Property of 3-((4-((4-(3-(3-(tert-butyl)-1-(6-methoxypyridin-3-yl)-1H-pyrazol-5-yl)ureido)naphthalen-1-yl)oxy)pyrimidin-2-yl)amino)phenyl methanesulfonate

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Technology Process of 3-((4-((4-(3-(3-(tert-butyl)-1-(6-methoxypyridin-3-yl)-1H-pyrazol-5-yl)ureido)naphthalen-1-yl)oxy)pyrimidin-2-yl)amino)phenyl methanesulfonate

There total 4 articles about 3-((4-((4-(3-(3-(tert-butyl)-1-(6-methoxypyridin-3-yl)-1H-pyrazol-5-yl)ureido)naphthalen-1-yl)oxy)pyrimidin-2-yl)amino)phenyl methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1610450-03-7
1-(3-(tert-butyl)-1-(6-methoxypyridin-3-yl)-1H-pyrazol-5-yl)-3-(4-((2-chloropyrimidin-4-yl)oxy)naphthalen-1-yl)urea

: 38164-50-0
3-aminophenyl methanesulfonate

: 1610449-25-6
3-((4-((4-(3-(3-(tert-butyl)-1-(6-methoxypyridin-3-yl)-1H-pyrazol-5-yl)ureido)naphthalen-1-yl)oxy)pyrimidin-2-yl)amino)phenyl methanesulfonate

Guidance literature:: With toluene-4-sulfonic acid; In N,N-dimethyl-formamide; at 70 ℃; for 4h;

Reference yield:

: 19013-29-7
3-nitrophenyl methane sulfonate

: 1610449-25-6
3-((4-((4-(3-(3-(tert-butyl)-1-(6-methoxypyridin-3-yl)-1H-pyrazol-5-yl)ureido)naphthalen-1-yl)oxy)pyrimidin-2-yl)amino)phenyl methanesulfonate

Guidance literature:: Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / ethanol

2: toluene-4-sulfonic acid / N,N-dimethyl-formamide / 4 h / 70 °C

With palladium 10% on activated carbon; hydrogen; toluene-4-sulfonic acid; In ethanol; N,N-dimethyl-formamide;

Reference yield:

: 1573025-19-0
phenyl (4-((2-chloropyrimidin-4-yl)oxy)naphthalen-1-yl)carbamate

: 1610449-25-6
3-((4-((4-(3-(3-(tert-butyl)-1-(6-methoxypyridin-3-yl)-1H-pyrazol-5-yl)ureido)naphthalen-1-yl)oxy)pyrimidin-2-yl)amino)phenyl methanesulfonate

Guidance literature:: Multi-step reaction with 2 steps

1: dmap / tetrahydrofuran / 58 h / 20 - 40 °C / Inert atmosphere

2: toluene-4-sulfonic acid / N,N-dimethyl-formamide / 4 h / 70 °C

With dmap; toluene-4-sulfonic acid; In tetrahydrofuran; N,N-dimethyl-formamide;