(S)-3-(2-(2-(4-(benzyloxy)phenyl)-1-(cyclohexanecarboxamido)ethyl)-5-phenylthiazole-4-carboxamido)benzoic acid

Base Information

Chemical Name:(S)-3-(2-(2-(4-(benzyloxy)phenyl)-1-(cyclohexanecarboxamido)ethyl)-5-phenylthiazole-4-carboxamido)benzoic acid
CAS No.:1489277-88-4
Molecular Formula:C₃₉H₃₇N₃O₅S
Molecular Weight:659.806
Hs Code.:

Synonyms:(S)-3-(2-(2-(4-(benzyloxy)phenyl)-1-(cyclohexanecarboxamido)ethyl)-5-phenylthiazole-4-carboxamido)benzoic acid

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Chemical Property of (S)-3-(2-(2-(4-(benzyloxy)phenyl)-1-(cyclohexanecarboxamido)ethyl)-5-phenylthiazole-4-carboxamido)benzoic acid

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Technology Process of (S)-3-(2-(2-(4-(benzyloxy)phenyl)-1-(cyclohexanecarboxamido)ethyl)-5-phenylthiazole-4-carboxamido)benzoic acid

There total 8 articles about (S)-3-(2-(2-(4-(benzyloxy)phenyl)-1-(cyclohexanecarboxamido)ethyl)-5-phenylthiazole-4-carboxamido)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1489277-82-8
(S)-methyl 3-(2-(2-(4-(benzyloxy)phenyl)-1-(cyclohexanecarboxamido)ethyl)-5-phenylthiazole-4-carboxamido)benzoate

: 1489277-88-4
(S)-3-(2-(2-(4-(benzyloxy)phenyl)-1-(cyclohexanecarboxamido)ethyl)-5-phenylthiazole-4-carboxamido)benzoic acid

Guidance literature:: With lithium hydroxide monohydrate; In tetrahydrofuran; methanol; water; at 50 ℃; for 2h;
DOI:10.1016/j.ejmech.2013.09.017

Reference yield:

: 1489279-14-2
(S)-methyl 3-(2-(2-(4-(benzyloxy)phenyl)-1-(tert-butoxycarbonylamino)ethyl)-5-phenylthiazole-4-carboxamido)benzoate

: 1489277-88-4
(S)-3-(2-(2-(4-(benzyloxy)phenyl)-1-(cyclohexanecarboxamido)ethyl)-5-phenylthiazole-4-carboxamido)benzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / ethyl acetate / 20 °C

2: triethylamine / dichloromethane / 20 °C / Cooling with ice

3: lithium hydroxide monohydrate / water; tetrahydrofuran; methanol / 2 h / 50 °C

With hydrogenchloride; lithium hydroxide monohydrate; triethylamine; In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate;
DOI:10.1016/j.ejmech.2013.09.017

Reference yield:

: 1489279-11-9
(S)-2-(2-(4-(benzyloxy)phenyl)-1-(tert-butoxycarbonylamino)ethyl)-5-phenylthiazole-4-carboxylic acid

: 1489277-88-4
(S)-3-(2-(2-(4-(benzyloxy)phenyl)-1-(cyclohexanecarboxamido)ethyl)-5-phenylthiazole-4-carboxamido)benzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: HATU; 4-methyl-morpholine / dichloromethane / 20 °C

2: hydrogenchloride / ethyl acetate / 20 °C

3: triethylamine / dichloromethane / 20 °C / Cooling with ice

4: lithium hydroxide monohydrate / water; tetrahydrofuran; methanol / 2 h / 50 °C

With 4-methyl-morpholine; hydrogenchloride; lithium hydroxide monohydrate; triethylamine; HATU; In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate;
DOI:10.1016/j.ejmech.2013.09.017