(S)-methyl 3-(2-(2-(4-(benzyloxy)phenyl)-1-(tert-butoxycarbonylamino)ethyl)-5-phenylthiazole-4-carboxamido)benzoate

Base Information

Chemical Name:(S)-methyl 3-(2-(2-(4-(benzyloxy)phenyl)-1-(tert-butoxycarbonylamino)ethyl)-5-phenylthiazole-4-carboxamido)benzoate
CAS No.:1489279-14-2
Molecular Formula:C₃₈H₃₇N₃O₆S
Molecular Weight:663.794
Hs Code.:

Synonyms:(S)-methyl 3-(2-(2-(4-(benzyloxy)phenyl)-1-(tert-butoxycarbonylamino)ethyl)-5-phenylthiazole-4-carboxamido)benzoate

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Chemical Property of (S)-methyl 3-(2-(2-(4-(benzyloxy)phenyl)-1-(tert-butoxycarbonylamino)ethyl)-5-phenylthiazole-4-carboxamido)benzoate

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Technology Process of (S)-methyl 3-(2-(2-(4-(benzyloxy)phenyl)-1-(tert-butoxycarbonylamino)ethyl)-5-phenylthiazole-4-carboxamido)benzoate

There total 4 articles about (S)-methyl 3-(2-(2-(4-(benzyloxy)phenyl)-1-(tert-butoxycarbonylamino)ethyl)-5-phenylthiazole-4-carboxamido)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 1489279-11-9
(S)-2-(2-(4-(benzyloxy)phenyl)-1-(tert-butoxycarbonylamino)ethyl)-5-phenylthiazole-4-carboxylic acid

: 87360-24-5
3-amino-benzoic acid methyl ester hydrochloride

: 1489279-14-2
(S)-methyl 3-(2-(2-(4-(benzyloxy)phenyl)-1-(tert-butoxycarbonylamino)ethyl)-5-phenylthiazole-4-carboxamido)benzoate

Guidance literature:: With 4-methyl-morpholine; HATU; In dichloromethane; at 20 ℃;
DOI:10.1016/j.ejmech.2013.09.017

Reference yield:

: 2130-96-3,54784-43-9
O-benzyl-N-tert-butoxycarbonyl-L-tyrosine

: 1489279-14-2
(S)-methyl 3-(2-(2-(4-(benzyloxy)phenyl)-1-(tert-butoxycarbonylamino)ethyl)-5-phenylthiazole-4-carboxamido)benzoate

Guidance literature:: Multi-step reaction with 4 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap; triethylamine / dichloromethane / 2 h / 20 °C

2: Lawessons reagent / tetrahydrofuran / 2 h / 65 °C

3: lithium hydroxide monohydrate / water; tetrahydrofuran / 50 °C

4: HATU; 4-methyl-morpholine / dichloromethane / 20 °C

With Lawessons reagent; 4-methyl-morpholine; dmap; lithium hydroxide monohydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; HATU; In tetrahydrofuran; dichloromethane; water;
DOI:10.1016/j.ejmech.2013.09.017

Reference yield:

: 95271-93-5
benzoylaminoacetic acid ethyl ester

: 1489279-14-2
(S)-methyl 3-(2-(2-(4-(benzyloxy)phenyl)-1-(tert-butoxycarbonylamino)ethyl)-5-phenylthiazole-4-carboxamido)benzoate

Guidance literature:: Multi-step reaction with 4 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap; triethylamine / dichloromethane / 2 h / 20 °C

2: Lawessons reagent / tetrahydrofuran / 2 h / 65 °C

3: lithium hydroxide monohydrate / water; tetrahydrofuran / 50 °C

4: HATU; 4-methyl-morpholine / dichloromethane / 20 °C

With Lawessons reagent; 4-methyl-morpholine; dmap; lithium hydroxide monohydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; HATU; In tetrahydrofuran; dichloromethane; water;
DOI:10.1016/j.ejmech.2013.09.017