(E)-1-[2-(4,5-dimethoxy-2-nitrostyryl)-1-(phenylsulfonyl)-1H-indol-3-yl]-2-(phenylsulfonyl)propan-1-one

Base Information

Chemical Name:(E)-1-[2-(4,5-dimethoxy-2-nitrostyryl)-1-(phenylsulfonyl)-1H-indol-3-yl]-2-(phenylsulfonyl)propan-1-one
CAS No.:1597408-61-1
Molecular Formula:C₃₃H₂₈N₂O₉S₂
Molecular Weight:660.725
Hs Code.:

Synonyms:(E)-1-[2-(4,5-dimethoxy-2-nitrostyryl)-1-(phenylsulfonyl)-1H-indol-3-yl]-2-(phenylsulfonyl)propan-1-one

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Chemical Property of (E)-1-[2-(4,5-dimethoxy-2-nitrostyryl)-1-(phenylsulfonyl)-1H-indol-3-yl]-2-(phenylsulfonyl)propan-1-one

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Technology Process of (E)-1-[2-(4,5-dimethoxy-2-nitrostyryl)-1-(phenylsulfonyl)-1H-indol-3-yl]-2-(phenylsulfonyl)propan-1-one

There total 5 articles about (E)-1-[2-(4,5-dimethoxy-2-nitrostyryl)-1-(phenylsulfonyl)-1H-indol-3-yl]-2-(phenylsulfonyl)propan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1597408-52-0
(E)-2-bromo-1-[2-(4,5-dimethoxy-2-nitrostyryl)-1-(phenylsulfonyl)-1H-indol-3-yl]propan-1-one

: 873-55-2
sodium benzenesulfonate

: 1597408-61-1
(E)-1-[2-(4,5-dimethoxy-2-nitrostyryl)-1-(phenylsulfonyl)-1H-indol-3-yl]-2-(phenylsulfonyl)propan-1-one

Guidance literature:: In N,N-dimethyl-formamide; at 20 ℃; for 3h; Inert atmosphere;
DOI:10.1002/ejoc.201301524

Reference yield:

: 95-20-5
2-methyl-1H-indole

: 1597408-61-1
(E)-1-[2-(4,5-dimethoxy-2-nitrostyryl)-1-(phenylsulfonyl)-1H-indol-3-yl]-2-(phenylsulfonyl)propan-1-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / tetrahydrofuran; hexane / 1 h / 0 °C / Inert atmosphere; Reflux

1.2: 0.42 h / 10 - 20 °C / Inert atmosphere

2.1: aluminum (III) chloride / dichloromethane / 3 h / 0 °C / Inert atmosphere

3.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 3 h / Inert atmosphere; Reflux

4.1: triphenylphosphine / tetrahydrofuran / 6 h / Inert atmosphere; Reflux

4.2: 40 h / 20 °C / Inert atmosphere

5.1: phenyltrimethylammonium tribromide / tetrahydrofuran / 3 h / 20 °C / Inert atmosphere

6.1: N,N-dimethyl-formamide / 3 h / 20 °C / Inert atmosphere

With aluminum (III) chloride; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); phenyltrimethylammonium tribromide; sodium hydride; triphenylphosphine; In tetrahydrofuran; tetrachloromethane; hexane; dichloromethane; N,N-dimethyl-formamide; 4.1: |Wittig Olefination / 4.2: |Wittig Olefination;
DOI:10.1002/ejoc.201301524

Reference yield:

: 1597408-46-2
(E)-1-[2-(4,5-dimethoxy-2-nitrostyryl)-1-(phenylsulfonyl)-1H-indol-3-yl]propan-1-one

: 1597408-61-1
(E)-1-[2-(4,5-dimethoxy-2-nitrostyryl)-1-(phenylsulfonyl)-1H-indol-3-yl]-2-(phenylsulfonyl)propan-1-one

Guidance literature:: Multi-step reaction with 2 steps

1: phenyltrimethylammonium tribromide / tetrahydrofuran / 3 h / 20 °C / Inert atmosphere

2: N,N-dimethyl-formamide / 3 h / 20 °C / Inert atmosphere

With phenyltrimethylammonium tribromide; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1002/ejoc.201301524