[4-((1S,2R,3S)-1,3-Bis-allyloxy-2-allyloxymethyl-4,4,4-trifluoro-butyl)-benzyloxy]-tert-butyl-diphenyl-silane

Base Information

• Chemical Name: [4-((1S,2R,3S)-1,3-Bis-allyloxy-2-allyloxymethyl-4,4,4-trifluoro-butyl)-benzyloxy]-tert-butyl-diphenyl-silane
• CAS No.: 211857-43-1
• Molecular Formula: C₃₇H₄₅F₃O₄Si
• Molecular Weight: 638.843

Synonyms:[4-((1S,2R,3S)-1,3-Bis-allyloxy-2-allyloxymethyl-4,4,4-trifluoro-butyl)-benzyloxy]-tert-butyl-diphenyl-silane

Chemical Property of [4-((1S,2R,3S)-1,3-Bis-allyloxy-2-allyloxymethyl-4,4,4-trifluoro-butyl)-benzyloxy]-tert-butyl-diphenyl-silane

Chemical Property:

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Technology Process of [4-((1S,2R,3S)-1,3-Bis-allyloxy-2-allyloxymethyl-4,4,4-trifluoro-butyl)-benzyloxy]-tert-butyl-diphenyl-silane

There total 2 articles about [4-((1S,2R,3S)-1,3-Bis-allyloxy-2-allyloxymethyl-4,4,4-trifluoro-butyl)-benzyloxy]-tert-butyl-diphenyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Acetic acid (S)-[4-(tert-butyl-diphenyl-silanyloxymethyl)-phenyl]-((2R,5R,6S)-2-tert-butyl-4-oxo-6-trifluoromethyl-[1,3]dioxan-5-yl)-methyl ester (211857-38-4) → [4-((1S,2R,3S)-1,3-Bis-allyloxy-2-allyloxymethyl-4,4,4-trifluoro-butyl)-benzyloxy]-tert-butyl-diphenyl-silane (211857-43-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / NaBH₄ / tetrahydrofuran; methanol / 7 h / Ambient temperature

2: 1.) NaH / 1.) THF, r.t., 30 min; 2.) THF, reflux, 4 h

With sodium tetrahydroborate; sodium hydride; In tetrahydrofuran; methanol;

DOI:10.1002/hlca.19980810515

Reference yield:

allyl bromide (106-95-6) + (1S,2R,3S)-1-[4-(tert-Butyl-diphenyl-silanyloxymethyl)-phenyl]-4,4,4-trifluoro-2-hydroxymethyl-butane-1,3-diol (211857-39-5) → [4-((1S,2R,3S)-1,3-Bis-allyloxy-2-allyloxymethyl-4,4,4-trifluoro-butyl)-benzyloxy]-tert-butyl-diphenyl-silane (211857-43-1)

Guidance literature:

With sodium hydride; Yield given. Multistep reaction; 1.) THF, r.t., 30 min; 2.) THF, reflux, 4 h;

DOI:10.1002/hlca.19980810515

Reference yield: 87.0%

[4-((1S,2R,3S)-1,3-Bis-allyloxy-2-allyloxymethyl-4,4,4-trifluoro-butyl)-benzyloxy]-tert-butyl-diphenyl-silane (211857-43-1) → [4-((1S,2R,3S)-1,3-Bis-allyloxy-2-allyloxymethyl-4,4,4-trifluoro-butyl)-phenyl]-methanol (211857-44-2)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 3.5h; Ambient temperature;

DOI:10.1002/hlca.19980810515

upstream raw materials:

allyl bromide

(1S,2R,3S)-1-[4-(tert-Butyl-diphenyl-silanyloxymethyl)-phenyl]-4,4,4-trifluoro-2-hydroxymethyl-butane-1,3-diol

Acetic acid (S)-[4-(tert-butyl-diphenyl-silanyloxymethyl)-phenyl]-((2R,5R,6S)-2-tert-butyl-4-oxo-6-trifluoromethyl-[1,3]dioxan-5-yl)-methyl ester

Downstream raw materials:

[4-((1S,2R,3S)-1,3-Bis-allyloxy-2-allyloxymethyl-4,4,4-trifluoro-butyl)-phenyl]-methanol

1-((1S,2R,3S)-1,3-Bis-allyloxy-2-allyloxymethyl-4,4,4-trifluoro-butyl)-4-bromomethyl-benzene

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