Acetic acid (S)-[4-(tert-butyl-diphenyl-silanyloxymethyl)-phenyl]-((2R,5R,6S)-2-tert-butyl-4-oxo-6-trifluoromethyl-[1,3]dioxan-5-yl)-methyl ester

Base Information

Chemical Name:Acetic acid (S)-[4-(tert-butyl-diphenyl-silanyloxymethyl)-phenyl]-((2R,5R,6S)-2-tert-butyl-4-oxo-6-trifluoromethyl-[1,3]dioxan-5-yl)-methyl ester
CAS No.:211857-38-4
Molecular Formula:C₃₅H₄₁F₃O₆Si
Molecular Weight:642.788
Hs Code.:

Synonyms:Acetic acid (S)-[4-(tert-butyl-diphenyl-silanyloxymethyl)-phenyl]-((2R,5R,6S)-2-tert-butyl-4-oxo-6-trifluoromethyl-[1,3]dioxan-5-yl)-methyl ester

Suppliers and Price of Acetic acid (S)-[4-(tert-butyl-diphenyl-silanyloxymethyl)-phenyl]-((2R,5R,6S)-2-tert-butyl-4-oxo-6-trifluoromethyl-[1,3]dioxan-5-yl)-methyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Acetic acid (S)-[4-(tert-butyl-diphenyl-silanyloxymethyl)-phenyl]-((2R,5R,6S)-2-tert-butyl-4-oxo-6-trifluoromethyl-[1,3]dioxan-5-yl)-methyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of Acetic acid (S)-[4-(tert-butyl-diphenyl-silanyloxymethyl)-phenyl]-((2R,5R,6S)-2-tert-butyl-4-oxo-6-trifluoromethyl-[1,3]dioxan-5-yl)-methyl ester

There total 1 articles about Acetic acid (S)-[4-(tert-butyl-diphenyl-silanyloxymethyl)-phenyl]-((2R,5R,6S)-2-tert-butyl-4-oxo-6-trifluoromethyl-[1,3]dioxan-5-yl)-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 131970-17-7
(2R,6S)-2-tert-Butyl-6-trifluoromethyl-[1,3]dioxan-4-one

: 75-36-5
acetyl chloride

: 196880-47-4
4-({[tert-butyl(diphenyl)silyl]oxy}methyl)benzaldehyde

: Acetic acid (R)-[4-(tert-butyl-diphenyl-silanyloxymethyl)-phenyl]-((2R,5R,6S)-2-tert-butyl-4-oxo-6-trifluoromethyl-[1,3]dioxan-5-yl)-methyl ester

: 211857-38-4
Acetic acid (S)-[4-(tert-butyl-diphenyl-silanyloxymethyl)-phenyl]-((2R,5R,6S)-2-tert-butyl-4-oxo-6-trifluoromethyl-[1,3]dioxan-5-yl)-methyl ester

Guidance literature:: With pyridine; tert.-butyl lithium; Yield given. Multistep reaction; 1.) THF, -78 deg C, 20 min; 2.) THF, -78 deg C, 6 h; 3.) THF, r.t., 16 h;
DOI:10.1002/hlca.19980810515

Reference yield: 87.0%

: 211857-38-4
Acetic acid (S)-[4-(tert-butyl-diphenyl-silanyloxymethyl)-phenyl]-((2R,5R,6S)-2-tert-butyl-4-oxo-6-trifluoromethyl-[1,3]dioxan-5-yl)-methyl ester

: 211857-39-5
(1S,2R,3S)-1-[4-(tert-Butyl-diphenyl-silanyloxymethyl)-phenyl]-4,4,4-trifluoro-2-hydroxymethyl-butane-1,3-diol

Guidance literature:: With sodium tetrahydroborate; In tetrahydrofuran; methanol; for 7h; Ambient temperature;
DOI:10.1002/hlca.19980810515

Reference yield:

: 211857-38-4
Acetic acid (S)-[4-(tert-butyl-diphenyl-silanyloxymethyl)-phenyl]-((2R,5R,6S)-2-tert-butyl-4-oxo-6-trifluoromethyl-[1,3]dioxan-5-yl)-methyl ester

: 211857-44-2
[4-((1S,2R,3S)-1,3-Bis-allyloxy-2-allyloxymethyl-4,4,4-trifluoro-butyl)-phenyl]-methanol

Guidance literature:: Multi-step reaction with 3 steps

1: 87 percent / NaBH₄ / tetrahydrofuran; methanol / 7 h / Ambient temperature

2: 1.) NaH / 1.) THF, r.t., 30 min; 2.) THF, reflux, 4 h

3: 87 percent / TBAF / tetrahydrofuran / 3.5 h / Ambient temperature

With sodium tetrahydroborate; tetrabutyl ammonium fluoride; sodium hydride; In tetrahydrofuran; methanol;
DOI:10.1002/hlca.19980810515