methyl (2S,3R,6S,8S)-8-tert-butyldiphenylsilyloxy-3,6-epoxy-2-methylnonanoate

Base Information

Chemical Name:methyl (2S,3R,6S,8S)-8-tert-butyldiphenylsilyloxy-3,6-epoxy-2-methylnonanoate
CAS No.:364597-77-3
Molecular Formula:C₂₇H₃₈O₄Si
Molecular Weight:454.682
Hs Code.:

Synonyms:methyl (2S,3R,6S,8S)-8-tert-butyldiphenylsilyloxy-3,6-epoxy-2-methylnonanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl (2S,3R,6S,8S)-8-tert-butyldiphenylsilyloxy-3,6-epoxy-2-methylnonanoate

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Technology Process of methyl (2S,3R,6S,8S)-8-tert-butyldiphenylsilyloxy-3,6-epoxy-2-methylnonanoate

There total 7 articles about methyl (2S,3R,6S,8S)-8-tert-butyldiphenylsilyloxy-3,6-epoxy-2-methylnonanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 364597-30-8
(R)-2-{(2R,5S)-5-[(S)-2-(tert-Butyl-diphenyl-silanyloxy)-propyl]-tetrahydro-furan-2-yl}-propionic acid

: 18107-18-1
diazomethyl-trimethyl-silane

: 364597-77-3
methyl (2S,3R,6S,8S)-8-tert-butyldiphenylsilyloxy-3,6-epoxy-2-methylnonanoate

Guidance literature:: DOI:10.1016/S0040-4039(01)00921-2

Reference yield:

: 364597-29-5
(2S,3R,6S,8S)-1-benzyloxy-8-tert-butyldiphenylsilyloxy-3,6-epoxy-2-methylnonane

: 364597-77-3
methyl (2S,3R,6S,8S)-8-tert-butyldiphenylsilyloxy-3,6-epoxy-2-methylnonanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 73 percent / H₂ / !0 percent Pd/C

2: 82 percent / PDC / dimethylformamide

With dipyridinium dichromate; hydrogen; !0 percent Pd/C; In N,N-dimethyl-formamide; 1: hydrogenlysis / 2: oxidation;
DOI:10.1016/S0040-4039(01)00921-2

Reference yield:

: 364597-27-3
(2S,3S,4S,6R,8S)-1-benzyloxy-8-tert-butyldiphenylsilyloxy-3,6-epoxy-2-methyl-4-(phenylseleno)nonane

: 364597-77-3
methyl (2S,3R,6S,8S)-8-tert-butyldiphenylsilyloxy-3,6-epoxy-2-methylnonanoate

Guidance literature:: Multi-step reaction with 4 steps

1: 85 percent / Bu₃SnH / AIBN

2: 73 percent / H₂ / !0 percent Pd/C

3: 82 percent / PDC / dimethylformamide

With dipyridinium dichromate; hydrogen; tri-n-butyl-tin hydride; 2,2'-azobis(isobutyronitrile); In N,N-dimethyl-formamide; 1: reduction / 2: hydrogenlysis / 3: oxidation;
DOI:10.1016/S0040-4039(01)00921-2