2-[1-[8-chloro-3-(cyclopropylmethyl)-1,2,4-triazolo[4,3-a]pyridin-7-yl]-4-piperidinyl]-3,5-difluoro-phenol

Base Information

Chemical Name:2-[1-[8-chloro-3-(cyclopropylmethyl)-1,2,4-triazolo[4,3-a]pyridin-7-yl]-4-piperidinyl]-3,5-difluoro-phenol
CAS No.:1376335-33-9
Molecular Formula:C₂₁H₂₁ClF₂N₄O
Molecular Weight:418.874
Hs Code.:

Synonyms:2-[1-[8-chloro-3-(cyclopropylmethyl)-1,2,4-triazolo[4,3-a]pyridin-7-yl]-4-piperidinyl]-3,5-difluoro-phenol

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Chemical Property of 2-[1-[8-chloro-3-(cyclopropylmethyl)-1,2,4-triazolo[4,3-a]pyridin-7-yl]-4-piperidinyl]-3,5-difluoro-phenol

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Technology Process of 2-[1-[8-chloro-3-(cyclopropylmethyl)-1,2,4-triazolo[4,3-a]pyridin-7-yl]-4-piperidinyl]-3,5-difluoro-phenol

There total 7 articles about 2-[1-[8-chloro-3-(cyclopropylmethyl)-1,2,4-triazolo[4,3-a]pyridin-7-yl]-4-piperidinyl]-3,5-difluoro-phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 11.2%

: 1376334-42-7
8-chloro-3-(cyclopropylmethyl)-7-[4-(2,4-difluoro-6-methoxyphenyl)-1-piperidinyl]-1,2,4-triazolo[4,3-a]pyridine

: 1376335-33-9
2-[1-[8-chloro-3-(cyclopropylmethyl)-1,2,4-triazolo[4,3-a]pyridin-7-yl]-4-piperidinyl]-3,5-difluoro-phenol

Guidance literature:: With boron tribromide; In dichloromethane; at 0 - 20 ℃; for 0.75h;
DOI:10.1021/jm300912k

Reference yield: 11.2%

: 1376335-33-9
2-[1-[8-chloro-3-(cyclopropylmethyl)-1,2,4-triazolo[4,3-a]pyridin-7-yl]-4-piperidinyl]-3,5-difluoro-phenol

Guidance literature:

Reference yield:

: 325486-43-9
2-bromo-3,5- difluoro-phenol

: 1376335-33-9
2-[1-[8-chloro-3-(cyclopropylmethyl)-1,2,4-triazolo[4,3-a]pyridin-7-yl]-4-piperidinyl]-3,5-difluoro-phenol

Guidance literature:: Multi-step reaction with 6 steps

1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 150 °C / Microwave irradiation

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane / 0.17 h / 150 °C / Microwave irradiation

3: 10 wt% Pd(OH)2 on carbon; hydrogen / ethanol / 80 °C

4: hydrogenchloride / methanol; isopropyl alcohol / 1.5 h / 20 °C

5: palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 125 °C

6: boron tribromide / dichloromethane / 0.75 h / 0 - 20 °C

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 10 wt% Pd(OH)2 on carbon; hydrogen; palladium diacetate; boron tribromide; potassium carbonate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In 1,4-dioxane; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; toluene;
DOI:10.1021/jm300912k