1-[N-(4-methoxyphenyl)-N-((E)-3-phenylacryloyl)aminomethyl]-2-oxocyclopentanecarboxylic acid ethyl ester

Base Information

• Chemical Name: 1-[N-(4-methoxyphenyl)-N-((E)-3-phenylacryloyl)aminomethyl]-2-oxocyclopentanecarboxylic acid ethyl ester
• CAS No.: 910042-23-8
• Molecular Formula: C₂₅H₂₇NO₅
• Molecular Weight: 421.493

Synonyms:1-[N-(4-methoxyphenyl)-N-((E)-3-phenylacryloyl)aminomethyl]-2-oxocyclopentanecarboxylic acid ethyl ester

Chemical Property of 1-[N-(4-methoxyphenyl)-N-((E)-3-phenylacryloyl)aminomethyl]-2-oxocyclopentanecarboxylic acid ethyl ester

Chemical Property:

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Technology Process of 1-[N-(4-methoxyphenyl)-N-((E)-3-phenylacryloyl)aminomethyl]-2-oxocyclopentanecarboxylic acid ethyl ester

There total 3 articles about 1-[N-(4-methoxyphenyl)-N-((E)-3-phenylacryloyl)aminomethyl]-2-oxocyclopentanecarboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

1-[(4-methoxyphenyl)aminomethyl]-2-oxocyclopentanecarboxylic acid ethyl ester (742680-95-1) + Cinnamoyl chloride (102-92-1,17082-09-6) → 1-[N-(4-methoxyphenyl)-N-((E)-3-phenylacryloyl)aminomethyl]-2-oxocyclopentanecarboxylic acid ethyl ester (910042-23-8)

Guidance literature:

With sodium carbonate; In dichloromethane; at 20 ℃; for 65h;

DOI:10.1021/ol061329d

Reference yield:

2-ethoxycarbonyl-1-cyclopentanone (611-10-9) → 1-[N-(4-methoxyphenyl)-N-((E)-3-phenylacryloyl)aminomethyl]-2-oxocyclopentanecarboxylic acid ethyl ester (910042-23-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 94 percent / KOH; H₂O / ethanol / 0.5 h / -20 °C

2: 65 percent / aq. Na₂CO₃ / CH₂Cl₂ / 65 h / 20 °C

With potassium hydroxide; water; sodium carbonate; In ethanol; dichloromethane;

DOI:10.1021/ol061329d

Reference yield:

4-methoxy-aniline (104-94-9) → 1-[N-(4-methoxyphenyl)-N-((E)-3-phenylacryloyl)aminomethyl]-2-oxocyclopentanecarboxylic acid ethyl ester (910042-23-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 94 percent / KOH; H₂O / ethanol / 0.5 h / -20 °C

2: 65 percent / aq. Na₂CO₃ / CH₂Cl₂ / 65 h / 20 °C

With potassium hydroxide; water; sodium carbonate; In ethanol; dichloromethane;

DOI:10.1021/ol061329d

upstream raw materials:

1-[(4-methoxyphenyl)aminomethyl]-2-oxocyclopentanecarboxylic acid ethyl ester

Cinnamoyl chloride

2-ethoxycarbonyl-1-cyclopentanone

4-methoxy-aniline

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