5'-O-dimethoxytrityl-3'-O-(2-cyanoethyl-N,N'-diisopropylphosphoramidite)-2'-O-neopentyluridine

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Chemical Name:5'-O-dimethoxytrityl-3'-O-(2-cyanoethyl-N,N'-diisopropylphosphoramidite)-2'-O-neopentyluridine
CAS No.:1422537-64-1
Molecular Formula:C₄₄H₅₇N₄O₉P
Molecular Weight:816.932
Hs Code.:

Synonyms:5'-O-dimethoxytrityl-3'-O-(2-cyanoethyl-N,N'-diisopropylphosphoramidite)-2'-O-neopentyluridine

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Chemical Property of 5'-O-dimethoxytrityl-3'-O-(2-cyanoethyl-N,N'-diisopropylphosphoramidite)-2'-O-neopentyluridine

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Technology Process of 5'-O-dimethoxytrityl-3'-O-(2-cyanoethyl-N,N'-diisopropylphosphoramidite)-2'-O-neopentyluridine

There total 5 articles about 5'-O-dimethoxytrityl-3'-O-(2-cyanoethyl-N,N'-diisopropylphosphoramidite)-2'-O-neopentyluridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1422537-63-0
5'-O-dimethoxytrityl-2'-O-neopentyluridine

: 102691-36-1
N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite

: 1422537-64-1
5'-O-dimethoxytrityl-3'-O-(2-cyanoethyl-N,N'-diisopropylphosphoramidite)-2'-O-neopentyluridine

Guidance literature:: With 4,5-dicyano-1H-imidazole; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;
DOI:10.1039/c2ob26871j

Reference yield:

: 58-96-8
uridine

: 1422537-64-1
5'-O-dimethoxytrityl-3'-O-(2-cyanoethyl-N,N'-diisopropylphosphoramidite)-2'-O-neopentyluridine

Guidance literature:: Multi-step reaction with 4 steps

1.1: bis(phenyl) carbonate / N,N-dimethyl-d₆-formamide / 85 °C / Inert atmosphere

1.2: 4 h / 120 °C

2.1: boron trifluoride diethyl etherate / N,N-dimethyl-formamide / 120 h / 120 °C

3.1: pyridine / 5 h / 0 - 20 °C

4.1: 4,5-dicyano-1H-imidazole / dichloromethane / 1 h / 20 °C / Inert atmosphere

With pyridine; bis(phenyl) carbonate; 4,5-dicyano-1H-imidazole; boron trifluoride diethyl etherate; In dichloromethane; N,N-dimethyl-formamide; N,N-dimethyl-d₆-formamide;
DOI:10.1039/c2ob26871j

Reference yield:

: 3736-77-4
2,2'-Anhydrouridine

: 1422537-64-1
5'-O-dimethoxytrityl-3'-O-(2-cyanoethyl-N,N'-diisopropylphosphoramidite)-2'-O-neopentyluridine

Guidance literature:: Multi-step reaction with 3 steps

1: boron trifluoride diethyl etherate / N,N-dimethyl-formamide / 120 h / 120 °C

2: pyridine / 5 h / 0 - 20 °C

3: 4,5-dicyano-1H-imidazole / dichloromethane / 1 h / 20 °C / Inert atmosphere

With pyridine; 4,5-dicyano-1H-imidazole; boron trifluoride diethyl etherate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/c2ob26871j