N-[(2R,3R)-2-(1,1-Dicyano-3-methyl-but-3-enyl)-4-oxo-azetidin-3-yl]-2-phenoxy-acetamide

Base Information

Chemical Name:N-[(2R,3R)-2-(1,1-Dicyano-3-methyl-but-3-enyl)-4-oxo-azetidin-3-yl]-2-phenoxy-acetamide
CAS No.:145050-19-7
Molecular Formula:C₁₈H₁₈N₄O₃
Molecular Weight:338.366
Hs Code.:

Synonyms:N-[(2R,3R)-2-(1,1-Dicyano-3-methyl-but-3-enyl)-4-oxo-azetidin-3-yl]-2-phenoxy-acetamide

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Chemical Property of N-[(2R,3R)-2-(1,1-Dicyano-3-methyl-but-3-enyl)-4-oxo-azetidin-3-yl]-2-phenoxy-acetamide

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Technology Process of N-[(2R,3R)-2-(1,1-Dicyano-3-methyl-but-3-enyl)-4-oxo-azetidin-3-yl]-2-phenoxy-acetamide

There total 1 articles about N-[(2R,3R)-2-(1,1-Dicyano-3-methyl-but-3-enyl)-4-oxo-azetidin-3-yl]-2-phenoxy-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 145050-18-6
2-(2-methylallyl)-malononitrile

: 103366-35-4
Acetic acid (2R,3R)-4-oxo-3-(2-phenoxy-acetylamino)-azetidin-2-yl ester

: 145050-19-7
N-[(2R,3R)-2-(1,1-Dicyano-3-methyl-but-3-enyl)-4-oxo-azetidin-3-yl]-2-phenoxy-acetamide

Guidance literature:: With lithium hexamethyldisilazane; In tetrahydrofuran; at -35 ℃; for 0.666667h;
DOI:10.1016/S0040-4039(00)60017-5

Reference yield:

: 145050-19-7
N-[(2R,3R)-2-(1,1-Dicyano-3-methyl-but-3-enyl)-4-oxo-azetidin-3-yl]-2-phenoxy-acetamide

: 145050-22-2,145107-73-9
(6R,7S)-5,5-Dicyano-3-methyl-7-{[1-(4-nitro-phenyl)-meth-(E)-ylidene]-amino}-8-oxo-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid allyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) O₃, 2.) DMS / 1.) CH₂Cl₂, -45 deg C

2: 100 percent / iPr₂NEt / CH₂Cl₂ / 0.5 h / -78 °C

3: 30 percent / P(OEt)3 / xylene / 0.33 h / Heating

With 2,3-dimercapto-succinic acid; ozone; N-ethyl-N,N-diisopropylamine; triethyl phosphite; In dichloromethane; xylene;
DOI:10.1016/S0040-4039(00)60017-5

Reference yield:

: 145050-19-7
N-[(2R,3R)-2-(1,1-Dicyano-3-methyl-but-3-enyl)-4-oxo-azetidin-3-yl]-2-phenoxy-acetamide

: 145050-22-2,145107-73-9
(6R,7R)-5,5-Dicyano-3-methyl-7-{[1-(4-nitro-phenyl)-meth-(E)-ylidene]-amino}-8-oxo-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid allyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) O₃, 2.) DMS / 1.) CH₂Cl₂, -45 deg C

2: 100 percent / iPr₂NEt / CH₂Cl₂ / 0.5 h / -78 °C

3: 30 percent / P(OEt)3 / xylene / 0.33 h / Heating

With 2,3-dimercapto-succinic acid; ozone; N-ethyl-N,N-diisopropylamine; triethyl phosphite; In dichloromethane; xylene;
DOI:10.1016/S0040-4039(00)60017-5