(5S)-(1H-imidazol-1-ylmethyl)-1-[[2-[1-(phenylmethyl)-1H-1,2,3,4-tetrazol-5-yl]phenyl]methyl]-2-pyrrolidinone

Base Information

Chemical Name:(5S)-(1H-imidazol-1-ylmethyl)-1-[[2-[1-(phenylmethyl)-1H-1,2,3,4-tetrazol-5-yl]phenyl]methyl]-2-pyrrolidinone
CAS No.:1308719-36-9
Molecular Formula:C₂₃H₂₃N₇O
Molecular Weight:413.482
Hs Code.:

Synonyms:(5S)-(1H-imidazol-1-ylmethyl)-1-[[2-[1-(phenylmethyl)-1H-1,2,3,4-tetrazol-5-yl]phenyl]methyl]-2-pyrrolidinone

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Chemical Property of (5S)-(1H-imidazol-1-ylmethyl)-1-[[2-[1-(phenylmethyl)-1H-1,2,3,4-tetrazol-5-yl]phenyl]methyl]-2-pyrrolidinone

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Technology Process of (5S)-(1H-imidazol-1-ylmethyl)-1-[[2-[1-(phenylmethyl)-1H-1,2,3,4-tetrazol-5-yl]phenyl]methyl]-2-pyrrolidinone

There total 9 articles about (5S)-(1H-imidazol-1-ylmethyl)-1-[[2-[1-(phenylmethyl)-1H-1,2,3,4-tetrazol-5-yl]phenyl]methyl]-2-pyrrolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 1308719-04-1
4-methylbenzenesulfonic acid [5-oxo-1-[[2-[1-(phenylmethyl)-1H-1,2,3,4-tetrazol-5-yl]phenyl]methyl]-(2S)-pyrrolidinyl]methyl ester

: 55986-39-5
lithium salt of imidazole

: 1308719-36-9
(5S)-(1H-imidazol-1-ylmethyl)-1-[[2-[1-(phenylmethyl)-1H-1,2,3,4-tetrazol-5-yl]phenyl]methyl]-2-pyrrolidinone

Guidance literature:: In N,N-dimethyl-formamide; at 50 ℃; Inert atmosphere;
DOI:10.1016/j.bmc.2011.03.044

Reference yield:

: 1308719-13-2
5-(2-methylphenyl)-1-(phenylmethyl)-1H-1,2,3,4-tetrazole

: 1308719-36-9
(5S)-(1H-imidazol-1-ylmethyl)-1-[[2-[1-(phenylmethyl)-1H-1,2,3,4-tetrazol-5-yl]phenyl]methyl]-2-pyrrolidinone

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 5 h / 80 °C

2.1: sodium hydride / tetrahydrofuran; paraffin oil / 0 - 20 °C

3.1: lithium borohydride / tetrahydrofuran / 20 °C / Inert atmosphere

3.2: 0 °C / Inert atmosphere

4.1: triethylamine / dichloromethane / 0 - 20 °C

5.1: N,N-dimethyl-formamide / 50 °C / Inert atmosphere

With N-Bromosuccinimide; lithium borohydride; 2,2'-azobis(isobutyronitrile); sodium hydride; triethylamine; In tetrahydrofuran; tetrachloromethane; dichloromethane; N,N-dimethyl-formamide; paraffin oil;
DOI:10.1016/j.bmc.2011.03.044

Reference yield:

: 1308719-18-7
5-[2-(bromomethyl)phenyl]-1-(phenylmethyl)-1H-1,2,3,4-tetrazole

: 1308719-36-9
(5S)-(1H-imidazol-1-ylmethyl)-1-[[2-[1-(phenylmethyl)-1H-1,2,3,4-tetrazol-5-yl]phenyl]methyl]-2-pyrrolidinone

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran; paraffin oil / 0 - 20 °C

2.1: lithium borohydride / tetrahydrofuran / 20 °C / Inert atmosphere

2.2: 0 °C / Inert atmosphere

3.1: triethylamine / dichloromethane / 0 - 20 °C

4.1: N,N-dimethyl-formamide / 50 °C / Inert atmosphere

With lithium borohydride; sodium hydride; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; paraffin oil;
DOI:10.1016/j.bmc.2011.03.044