4-methylbenzenesulfonic acid [5-oxo-1-[[2-[1-(phenylmethyl)-1H-1,2,3,4-tetrazol-5-yl]phenyl]methyl]-(2S)-pyrrolidinyl]methyl ester

Base Information

Chemical Name:4-methylbenzenesulfonic acid [5-oxo-1-[[2-[1-(phenylmethyl)-1H-1,2,3,4-tetrazol-5-yl]phenyl]methyl]-(2S)-pyrrolidinyl]methyl ester
CAS No.:1308719-04-1
Molecular Formula:C₂₇H₂₇N₅O₄S
Molecular Weight:517.608
Hs Code.:

Synonyms:4-methylbenzenesulfonic acid [5-oxo-1-[[2-[1-(phenylmethyl)-1H-1,2,3,4-tetrazol-5-yl]phenyl]methyl]-(2S)-pyrrolidinyl]methyl ester

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Chemical Property of 4-methylbenzenesulfonic acid [5-oxo-1-[[2-[1-(phenylmethyl)-1H-1,2,3,4-tetrazol-5-yl]phenyl]methyl]-(2S)-pyrrolidinyl]methyl ester

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Technology Process of 4-methylbenzenesulfonic acid [5-oxo-1-[[2-[1-(phenylmethyl)-1H-1,2,3,4-tetrazol-5-yl]phenyl]methyl]-(2S)-pyrrolidinyl]methyl ester

There total 8 articles about 4-methylbenzenesulfonic acid [5-oxo-1-[[2-[1-(phenylmethyl)-1H-1,2,3,4-tetrazol-5-yl]phenyl]methyl]-(2S)-pyrrolidinyl]methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1308718-93-5
(5S)-(hydroxymethyl)-1-[[2-[1-(phenylmethyl)-1H-1,2,3,4-tetrazol-5-yl]phenyl]methyl]-2-pyrrolidinone

: 98-59-9
p-toluenesulfonyl chloride

: 1308719-04-1
4-methylbenzenesulfonic acid [5-oxo-1-[[2-[1-(phenylmethyl)-1H-1,2,3,4-tetrazol-5-yl]phenyl]methyl]-(2S)-pyrrolidinyl]methyl ester

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃;
DOI:10.1016/j.bmc.2011.03.044

Reference yield:

: 1308719-13-2
5-(2-methylphenyl)-1-(phenylmethyl)-1H-1,2,3,4-tetrazole

: 1308719-04-1
4-methylbenzenesulfonic acid [5-oxo-1-[[2-[1-(phenylmethyl)-1H-1,2,3,4-tetrazol-5-yl]phenyl]methyl]-(2S)-pyrrolidinyl]methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 5 h / 80 °C

2.1: sodium hydride / tetrahydrofuran; paraffin oil / 0 - 20 °C

3.1: lithium borohydride / tetrahydrofuran / 20 °C / Inert atmosphere

3.2: 0 °C / Inert atmosphere

4.1: triethylamine / dichloromethane / 0 - 20 °C

With N-Bromosuccinimide; lithium borohydride; 2,2'-azobis(isobutyronitrile); sodium hydride; triethylamine; In tetrahydrofuran; tetrachloromethane; dichloromethane; paraffin oil;
DOI:10.1016/j.bmc.2011.03.044

Reference yield:

: 51449-86-6
5-(2-methylphenyl)-1H-tetrazole

: 1308719-04-1
4-methylbenzenesulfonic acid [5-oxo-1-[[2-[1-(phenylmethyl)-1H-1,2,3,4-tetrazol-5-yl]phenyl]methyl]-(2S)-pyrrolidinyl]methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / acetone / 1 h / 50 °C / Inert atmosphere

2.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 5 h / 80 °C

3.1: sodium hydride / tetrahydrofuran; paraffin oil / 0 - 20 °C

4.1: lithium borohydride / tetrahydrofuran / 20 °C / Inert atmosphere

4.2: 0 °C / Inert atmosphere

5.1: triethylamine / dichloromethane / 0 - 20 °C

With N-Bromosuccinimide; lithium borohydride; 2,2'-azobis(isobutyronitrile); sodium hydride; potassium carbonate; triethylamine; In tetrahydrofuran; tetrachloromethane; dichloromethane; acetone; paraffin oil;
DOI:10.1016/j.bmc.2011.03.044