PROGESTERONE-2,2,4,6,6,17ALPHA,21,21,21-D9

Base Information

• Chemical Name: PROGESTERONE-2,2,4,6,6,17ALPHA,21,21,21-D9
• CAS No.: 15775-74-3
• Molecular Formula: C₂₁H₃₀O₂
• Molecular Weight: 323.397
• Hs Code.: 9999999999
• Mol file: 15775-74-3.mol

Synonyms:Progesterone-2,2,4,6,6,17,21,21,21-d9(8CI); 2,2,4,6,6,17,21,21,21-d9-Progesterone

Chemical Property of PROGESTERONE-2,2,4,6,6,17ALPHA,21,21,21-D9

Chemical Property:

• Melting Point: 128-132 °C
• Flash Point: 2℃
• PSA: 34.14000
• LogP: 4.72350
• Storage Temp.: ?20°C
• Solubility.: Acetone (Slightly), Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

98%,99%, ^*data from raw suppliers

Progesterone-d9 ^*data from reagent suppliers

Safty Information:

• Pictogram(s): F,Xn
• Hazard Codes: F,Xn
• Statements: 11-20/21/22-36-40
• Safety Statements: 16-36/37

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Progesterone-d9 is intended for use as an internal standard for the quantification of Progesterone by GC- or LC-mass spectrometry. Steroid hormone produced by the corpus luteum. Induces maturation and secretory activity of the uterine endothelium; suppresses ovulation. Progesterone is implicated in the etiology of breast cancer.

Technology Process of PROGESTERONE-2,2,4,6,6,17ALPHA,21,21,21-D9

There total 4 articles about PROGESTERONE-2,2,4,6,6,17ALPHA,21,21,21-D9 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

Progesterone (57-83-0) → progesterone-d9 (15775-74-3)

Guidance literature:

With d⁽⁴⁾-methanol; prenyl bromide; at 28 ℃; for 24h;

DOI:10.1039/d1ob01275d

Reference yield:

→ 2,2,4,6,6,17,21,21,21-d(9)-Progesteron (15775-74-3)

Guidance literature:

Progesteron, Methanol-d1, NaOMe;

DOI:10.1021/ja00806a037

Reference yield:

→ 2,2,4,6,6,17,21,21,21-nonadeuterio-pregn-4-ene-3,20-dione (15775-74-3)

Guidance literature:

Progesteron, Pt(PEt3)3, D2O;

DOI:10.1021/ja00502a017

upstream raw materials:

Progesterone

Refernces

• 1、 Darshana, Dhanushka,Sureram, Sanya,Mahidol, Chulabhorn,Ruchirawat, Somsak,Kittakoop, Prasat. "Spontaneous conversion of prenyl halides to acids: application in metal-free preparation of deuterated compounds under mild conditions". supporting information. p. 7390 - 7402. Retrieved 2021/09/07.
• 2、 Holland,Auret. "The mechanism of the microbial hydroxylation of steroids. Part I. The C 21 hydroxylation of progesterone by Aspergillus niger ATCC 9142". . p. 845 - 854. Retrieved 2007/10/06.