4-(9-(1-benzyl-2-methyl-1H-indol-3-yl)-2,3,4,4a,9,9a-hexahydro-1H-xanthen-4a-yl)morpholine

Base Information

Chemical Name:4-(9-(1-benzyl-2-methyl-1H-indol-3-yl)-2,3,4,4a,9,9a-hexahydro-1H-xanthen-4a-yl)morpholine
CAS No.:1611470-95-1
Molecular Formula:C₃₃H₃₆N₂O₂
Molecular Weight:492.661
Hs Code.:

Synonyms:4-(9-(1-benzyl-2-methyl-1H-indol-3-yl)-2,3,4,4a,9,9a-hexahydro-1H-xanthen-4a-yl)morpholine

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Chemical Property of 4-(9-(1-benzyl-2-methyl-1H-indol-3-yl)-2,3,4,4a,9,9a-hexahydro-1H-xanthen-4a-yl)morpholine

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Technology Process of 4-(9-(1-benzyl-2-methyl-1H-indol-3-yl)-2,3,4,4a,9,9a-hexahydro-1H-xanthen-4a-yl)morpholine

There total 6 articles about 4-(9-(1-benzyl-2-methyl-1H-indol-3-yl)-2,3,4,4a,9,9a-hexahydro-1H-xanthen-4a-yl)morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.5%

: 1611470-83-7
4-(9-(2-methyl-1H-indol-3-yl)-2,3,4,4a,9,9a-hexahydro-1H-xanthen-4a-yl)morpholine

: 100-39-0
benzyl bromide

: 1611470-95-1
4-(9-(1-benzyl-2-methyl-1H-indol-3-yl)-2,3,4,4a,9,9a-hexahydro-1H-xanthen-4a-yl)morpholine

Guidance literature:: 4-(9-(2-methyl-1H-indol-3-yl)-2,3,4,4a,9,9a-hexahydro-1H-xanthen-4a-yl)morpholine; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 0.0333333h; Inert atmosphere;

benzyl bromide; In tetrahydrofuran; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1016/j.cclet.2014.03.017

Reference yield:

: 670-80-4
4-cyclohexen-1-ylmorpholine

: 1611470-95-1
4-(9-(1-benzyl-2-methyl-1H-indol-3-yl)-2,3,4,4a,9,9a-hexahydro-1H-xanthen-4a-yl)morpholine

Guidance literature:: Multi-step reaction with 2 steps

1.1: 0.05 h / 165 °C

2.1: sodium hydride / tetrahydrofuran / 0.03 h / 20 °C / Inert atmosphere

2.2: 2 h / 20 °C / Inert atmosphere

With sodium hydride; In tetrahydrofuran;
DOI:10.1016/j.cclet.2014.03.017

Reference yield:

: 108-94-1,11119-77-0,9003-41-2,9075-99-4
cyclohexanone

: 1611470-95-1
4-(9-(1-benzyl-2-methyl-1H-indol-3-yl)-2,3,4,4a,9,9a-hexahydro-1H-xanthen-4a-yl)morpholine

Guidance literature:: Multi-step reaction with 3 steps

1.1: toluene-4-sulfonic acid / toluene / 6 h / Reflux

2.1: 0.05 h / 165 °C

3.1: sodium hydride / tetrahydrofuran / 0.03 h / 20 °C / Inert atmosphere

3.2: 2 h / 20 °C / Inert atmosphere

With sodium hydride; toluene-4-sulfonic acid; In tetrahydrofuran; toluene;
DOI:10.1016/j.cclet.2014.03.017