Technology Process of (R)-6-(tert-butyldiphenylsilyloxy)pentadec-1-en-3-one
There total 6 articles about (R)-6-(tert-butyldiphenylsilyloxy)pentadec-1-en-3-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
vinyl magnesium bromide;
In
tetrahydrofuran;
at -78 ℃;
for 2h;
Inert atmosphere;
DOI:10.1016/j.tet.2014.05.021
- Guidance literature:
-
Multi-step reaction with 4 steps
1: dimethyl sulfide borane / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere
2: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene / dichloromethane; water / 3 h / 20 °C / Inert atmosphere
3: dmap; triethylamine; N,O-dimethylhydroxylamine*hydrochloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 6 h / 20 °C / Inert atmosphere
4: vinyl magnesium bromide / tetrahydrofuran / 2 h / -78 °C / Inert atmosphere
With
dmap; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene; vinyl magnesium bromide; N,O-dimethylhydroxylamine*hydrochloride; dimethyl sulfide borane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine;
In
tetrahydrofuran; dichloromethane; water;
DOI:10.1016/j.tet.2014.05.021
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene / dichloromethane; water / 3 h / 20 °C / Inert atmosphere
2: dmap; triethylamine; N,O-dimethylhydroxylamine*hydrochloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 6 h / 20 °C / Inert atmosphere
3: vinyl magnesium bromide / tetrahydrofuran / 2 h / -78 °C / Inert atmosphere
With
dmap; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene; vinyl magnesium bromide; N,O-dimethylhydroxylamine*hydrochloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine;
In
tetrahydrofuran; dichloromethane; water;
DOI:10.1016/j.tet.2014.05.021
