3-pyridyl phenyl sulfoxide

Base Information

• Chemical Name: 3-pyridyl phenyl sulfoxide
• CAS No.: 71257-51-7
• Molecular Formula: C₁₁H₉NOS
• Molecular Weight: 203.265
• Mol file: 71257-51-7.mol

Synonyms:3-pyridyl phenyl sulfoxide

Chemical Property of 3-pyridyl phenyl sulfoxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-pyridyl phenyl sulfoxide

There total 6 articles about 3-pyridyl phenyl sulfoxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

bromobenzene (108-86-1,52753-63-6) + benzyl 3-pyridyl sulfoxide → 3-pyridyl phenyl sulfoxide (71257-51-7)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; cyclopentyl methyl ether; sodium t-butanolate; nixantphos; at 110 ℃; for 12h; Inert atmosphere;

DOI:10.1002/anie.201307172

Reference yield: 89.0%

3-Bromopyridine (626-55-1,163928-56-1) + benzyl phenyl sulfoxide (7417-81-4,20246-02-0,73610-10-3,210539-77-8,833-82-9) → 3-pyridyl phenyl sulfoxide (71257-51-7)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; cyclopentyl methyl ether; sodium t-butanolate; nixantphos; at 110 ℃; for 24h; Inert atmosphere;

DOI:10.1002/anie.201307172

Reference yield: 85.0%

3-Bromopyridine (626-55-1,163928-56-1) + 1-benzenesulfinyl-2-trimethylsilylethane (85533-19-3) → 3-pyridyl phenyl sulfoxide (71257-51-7)

Guidance literature:

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; cesium fluoride; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In 2-methyltetrahydrofuran; at 24 - 80 ℃; for 24h; Microwave irradiation; Inert atmosphere; Sealed tube;

DOI:10.1021/acs.orglett.6b00073

upstream raw materials:

3-phenylthiopyridine

bromobenzene

3-Bromopyridine

benzyl phenyl sulfoxide

Downstream raw materials:

1,1'-sulfinylbisbenzene

1-Pyridin-3-yl-cyclohex-2-enol

(S_S)-3-(p-tolylsulfinyl)pyridine

1-pyridin-3-yl-cyclohexanol