(4-phenethylcarbamoyl-1H-isoquinolin-2-yl)-acetic acid ethyl ester

Base Information

• Chemical Name: (4-phenethylcarbamoyl-1H-isoquinolin-2-yl)-acetic acid ethyl ester
• CAS No.: 671234-92-7
• Molecular Formula: C₂₂H₂₄N₂O₃
• Molecular Weight: 364.444
• Mol file: 671234-92-7.mol

Synonyms:(4-phenethylcarbamoyl-1H-isoquinolin-2-yl)-acetic acid ethyl ester

Chemical Property of (4-phenethylcarbamoyl-1H-isoquinolin-2-yl)-acetic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of (4-phenethylcarbamoyl-1H-isoquinolin-2-yl)-acetic acid ethyl ester

There total 4 articles about (4-phenethylcarbamoyl-1H-isoquinolin-2-yl)-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

2-(ethoxycarbonylmethyl)-4-(phenethylcarbamoyl)isoquinolinium bromide → (4-phenethylcarbamoyl-1H-isoquinolin-2-yl)-acetic acid ethyl ester (671234-92-7)

Guidance literature:

With 1-benzyl-1,2-dihydroisonicotinamide; In methanol; at 0 ℃; for 4h;

DOI:10.1002/ardp.200300764

Reference yield:

4-isoquinolinecarboxylic acid (7159-36-6) → (4-phenethylcarbamoyl-1H-isoquinolin-2-yl)-acetic acid ethyl ester (671234-92-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: ethyl chloroformate; Et₃N / CHCl₃ / 0.5 h / 5 - 10 °C

1.2: 71 percent / Et₃N / CHCl₃ / 5 h / 20 °C

2.1: 75 percent / acetone / Heating

3.1: 78 percent / 1-benzyl-1,2-dihydroisonicotinamide / methanol / 4 h / 0 °C

With chloroformic acid ethyl ester; triethylamine; 1-benzyl-1,2-dihydroisonicotinamide; In methanol; chloroform; acetone;

DOI:10.1002/ardp.200300764

Reference yield:

phenethylamine (64-04-0) → (4-phenethylcarbamoyl-1H-isoquinolin-2-yl)-acetic acid ethyl ester (671234-92-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: ethyl chloroformate; Et₃N / CHCl₃ / 0.5 h / 5 - 10 °C

1.2: 71 percent / Et₃N / CHCl₃ / 5 h / 20 °C

2.1: 75 percent / acetone / Heating

3.1: 78 percent / 1-benzyl-1,2-dihydroisonicotinamide / methanol / 4 h / 0 °C

With chloroformic acid ethyl ester; triethylamine; 1-benzyl-1,2-dihydroisonicotinamide; In methanol; chloroform; acetone;

DOI:10.1002/ardp.200300764

upstream raw materials:

4-isoquinolinecarboxylic acid

phenethylamine

4-(N-β-phenethylcarbamoyl)isoquinoline