7159-36-6

Usage

Uses

Used in Pharmaceutical Industry:
Isoquinoline-4-carboxylic acid is used as a synthetic intermediate for the development of various pharmaceuticals, leveraging its potential anti-inflammatory, antibacterial, and antifungal properties. Its incorporation into drug molecules can lead to the creation of novel therapeutic agents that address a range of health conditions.
Used in Agrochemical Industry:
In the agrochemical sector, Isoquinoline-4-carboxylic acid is utilized as a precursor in the synthesis of bioactive compounds, contributing to the development of new pesticides and other agrochemicals that can enhance crop protection and yield.
Used in Materials Chemistry:
Isoquinoline-4-carboxylic acid is employed in materials chemistry for its potential to contribute to the synthesis of novel materials with unique properties, such as those with enhanced stability or specific interactions, which can be applied in various industrial applications.
Used in Natural Product Synthesis:
Isoquinoline-4-carboxylic acid is also used as a key component in the synthesis of natural products, facilitating the production of complex organic molecules that can be found in nature and have potential applications in medicine, fragrances, or other industries.

InChI:InChI=1/C10H7NO2/c12-10(13)9-6-11-5-7-3-1-2-4-8(7)9/h1-6H,(H,12,13)

Upstream product

• 1532-97-4 4-bromoisoquinoline 
• 34846-65-6 isoquinoline-4-carbonitrile 
• 93830-64-9 4-lithioisoquinoline 
• 60-29-7 diethyl ether 
• 124-38-9 carbon dioxide 
• 119-65-3 isoquinoline 
• 34784-02-6 3-bromoisoquinoline 

Downstream Products

• 50741-47-4 4-ethoxycarbonylisoquinoline 
• 20317-40-2 methyl isoquinoline-4-carboxylate 
• 671234-87-0 4-(N-β-phenethylcarbamoyl)isoquinoline 
• 671234-92-7 (4-phenethylcarbamoyl-1H-isoquinolin-2-yl)-acetic acid ethyl ester 
• 671234-93-8 (4-phenethylcarbamoyl-1H-isoquinolin-2-yl)-acetic acid isopropyl ester 
• 1092768-77-8 C₂₆H₂₇ClN₂O₃ 
• 370580-85-1 C₁₀H₆ClNO 
• 1532-84-9 isoquinolin-1-ylamine 

Relevant academic research and scientific papers

CANNABINOID RECEPTOR MODULATORS

Compounds of Formula (I) along with processes for their preparation that are useful for treating, managing and/or lessening the diseases, disorders, syndromes or conditions associated with the modulation of cannabinoid (CB) receptors. Methods of treating, managing and/or lessening the diseases, disorders, syndromes or conditions associated with the modulation of cannabinoid (CB) receptors of Formula (I).

CANNABINOID RECEPTOR MODULATORS

Compounds of Formula (I) along with processes for their preparation that are useful for treating, managing and/or lessening the diseases, disorders, syndromes or conditions associated with the modulation of cannabinoid (CB) receptors. Methods of treating, managing and/or lessening the diseases, disorders, syndromes or conditions associated with the modulation of cannabinoid (CB) receptors of Formula (I).

1,2-Dihydroisoquinoline-N-acetic acid derivatives as new carriers for brain-specific delivery II: Delivery of phenethylamine as model drug

N-alkyloxycarbonylmethyl-1,2-dihydroisoquinolin-4-carboxylic acid derivatives 7 a-c were synthesized as new carriers for brain specific delivery. The design of the carrier systems are based on sequential hydrolysis at the acetic acid ester group linked to dihydroisoquinoline nitrogen followed by ring oxidation and formation of quaternary isoquinolinium derivatives which are then hydrolyzed to release the drug. Once the carrier system is administered, a sequential enzymatic process will take place resulting in significant increase in its rate of oxidation, the key factor in brain specific delivery. The chemical stability of the synthesized carrier system was investigated in aqueous buffer solutions and ferricyanide reagent and proofed to be quite stable against hydration and oxidation during formulation and storage. Furthermore, enzymatic stability was also investigated in 80% human plasma and 20% rabbit brain homogenate. Both oxidation and hydrolysis were found to take place; however, hydrolysis was the major route. In vivo distribution of the ethyl ester derivative 7 b was studied in rats and showed that the concentration of the quaternary product is increasing in the brain and cleared from blood with time.