(E)-(S)-6-Cyclohexyl-3,3-difluoro-2-isobutyl-hex-4-enimidic acid ethyl ester

Base Information

Chemical Name:(E)-(S)-6-Cyclohexyl-3,3-difluoro-2-isobutyl-hex-4-enimidic acid ethyl ester
CAS No.:128707-36-8
Molecular Formula:C₁₈H₃₁F₂NO
Molecular Weight:315.447
Hs Code.:

Synonyms:(E)-(S)-6-Cyclohexyl-3,3-difluoro-2-isobutyl-hex-4-enimidic acid ethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-(S)-6-Cyclohexyl-3,3-difluoro-2-isobutyl-hex-4-enimidic acid ethyl ester

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Technology Process of (E)-(S)-6-Cyclohexyl-3,3-difluoro-2-isobutyl-hex-4-enimidic acid ethyl ester

There total 3 articles about (E)-(S)-6-Cyclohexyl-3,3-difluoro-2-isobutyl-hex-4-enimidic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 128707-35-7
(E)-(S)-6-Cyclohexyl-3,3-difluoro-2-isobutyl-hex-4-enoic acid amide

: 128707-36-8
(E)-(S)-6-Cyclohexyl-3,3-difluoro-2-isobutyl-hex-4-enimidic acid ethyl ester

Guidance literature:: In dichloromethane; at 25 ℃; for 24h;
DOI:10.1021/ja00173a066

Reference yield:

: 121584-87-0
(E)-(R)-6-Cyclohexyl-3,3-difluoro-2-isobutyl-hex-4-enoyl chloride

: 128707-36-8
(E)-(S)-6-Cyclohexyl-3,3-difluoro-2-isobutyl-hex-4-enimidic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 75 percent / NH₃ / CH₂Cl₂ / 0 °C

2: 95 percent / CH₂Cl₂ / 24 h / 25 °C

With ammonia; In dichloromethane;
DOI:10.1021/ja00173a066

Reference yield:

: 128707-34-6
(E)-(S)-6-Cyclohexyl-3,3-difluoro-2-isobutyl-hex-4-enoic acid

: 128707-36-8
(E)-(S)-6-Cyclohexyl-3,3-difluoro-2-isobutyl-hex-4-enimidic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: (COCl)2, DMF / toluene / 25 °C

2: 75 percent / NH₃ / CH₂Cl₂ / 0 °C

3: 95 percent / CH₂Cl₂ / 24 h / 25 °C

With oxalyl dichloride; ammonia; N,N-dimethyl-formamide; In dichloromethane; toluene;
DOI:10.1021/ja00173a066