(2S,3S,5S)-2-Cyclohexylmethyl-6-ethoxy-4,4-difluoro-3-iodo-5-isobutyl-2,3,4,5-tetrahydro-pyridine

Base Information

Chemical Name:(2S,3S,5S)-2-Cyclohexylmethyl-6-ethoxy-4,4-difluoro-3-iodo-5-isobutyl-2,3,4,5-tetrahydro-pyridine
CAS No.:128707-37-9
Molecular Formula:C₁₈H₃₀F₂INO
Molecular Weight:441.344
Hs Code.:

Synonyms:(2S,3S,5S)-2-Cyclohexylmethyl-6-ethoxy-4,4-difluoro-3-iodo-5-isobutyl-2,3,4,5-tetrahydro-pyridine

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Chemical Property of (2S,3S,5S)-2-Cyclohexylmethyl-6-ethoxy-4,4-difluoro-3-iodo-5-isobutyl-2,3,4,5-tetrahydro-pyridine

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Technology Process of (2S,3S,5S)-2-Cyclohexylmethyl-6-ethoxy-4,4-difluoro-3-iodo-5-isobutyl-2,3,4,5-tetrahydro-pyridine

There total 4 articles about (2S,3S,5S)-2-Cyclohexylmethyl-6-ethoxy-4,4-difluoro-3-iodo-5-isobutyl-2,3,4,5-tetrahydro-pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 128707-36-8
(E)-(S)-6-Cyclohexyl-3,3-difluoro-2-isobutyl-hex-4-enimidic acid ethyl ester

: 128707-37-9
(2S,3S,5S)-2-Cyclohexylmethyl-6-ethoxy-4,4-difluoro-3-iodo-5-isobutyl-2,3,4,5-tetrahydro-pyridine

Guidance literature:: With 4,4'-dithiobis(2-methyl-6-tert.butylphenol); iodine; sodium hydrogencarbonate; In dichloromethane; water; at 25 ℃; for 24h; Yield given;
DOI:10.1021/ja00173a066

Reference yield:

: 128707-35-7
(E)-(S)-6-Cyclohexyl-3,3-difluoro-2-isobutyl-hex-4-enoic acid amide

: 128707-37-9
(2S,3S,5S)-2-Cyclohexylmethyl-6-ethoxy-4,4-difluoro-3-iodo-5-isobutyl-2,3,4,5-tetrahydro-pyridine

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / CH₂Cl₂ / 24 h / 25 °C

2: iodine, NaHCO₃, 4,4'-thiobis(2-tert-butyl-6-methylphenol (TBP) / CH₂Cl₂; H₂O / 24 h / 25 °C

With 4,4'-dithiobis(2-methyl-6-tert.butylphenol); iodine; sodium hydrogencarbonate; In dichloromethane; water;
DOI:10.1021/ja00173a066

Reference yield:

: 121584-87-0
(E)-(R)-6-Cyclohexyl-3,3-difluoro-2-isobutyl-hex-4-enoyl chloride

: 128707-37-9
(2S,3S,5S)-2-Cyclohexylmethyl-6-ethoxy-4,4-difluoro-3-iodo-5-isobutyl-2,3,4,5-tetrahydro-pyridine

Guidance literature:: Multi-step reaction with 3 steps

1: 75 percent / NH₃ / CH₂Cl₂ / 0 °C

2: 95 percent / CH₂Cl₂ / 24 h / 25 °C

3: iodine, NaHCO₃, 4,4'-thiobis(2-tert-butyl-6-methylphenol (TBP) / CH₂Cl₂; H₂O / 24 h / 25 °C

With 4,4'-dithiobis(2-methyl-6-tert.butylphenol); ammonia; iodine; sodium hydrogencarbonate; In dichloromethane; water;
DOI:10.1021/ja00173a066