5’-S-acetyl-N-4-benzoyl-3’-O-(4,4-dimethoxytriphenyl)methyl-2’,5’-deoxy-5’-thiocytidine

Base Information

Chemical Name:5’-S-acetyl-N-4-benzoyl-3’-O-(4,4-dimethoxytriphenyl)methyl-2’,5’-deoxy-5’-thiocytidine
CAS No.:177738-37-3
Molecular Formula:C₃₉H₃₇N₃O₇S
Molecular Weight:691.805
Hs Code.:

Synonyms:5’-S-acetyl-N-4-benzoyl-3’-O-(4,4-dimethoxytriphenyl)methyl-2’,5’-deoxy-5’-thiocytidine

Suppliers and Price of 5’-S-acetyl-N-4-benzoyl-3’-O-(4,4-dimethoxytriphenyl)methyl-2’,5’-deoxy-5’-thiocytidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5’-S-acetyl-N-4-benzoyl-3’-O-(4,4-dimethoxytriphenyl)methyl-2’,5’-deoxy-5’-thiocytidine

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Technology Process of 5’-S-acetyl-N-4-benzoyl-3’-O-(4,4-dimethoxytriphenyl)methyl-2’,5’-deoxy-5’-thiocytidine

There total 2 articles about 5’-S-acetyl-N-4-benzoyl-3’-O-(4,4-dimethoxytriphenyl)methyl-2’,5’-deoxy-5’-thiocytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 172161-64-7
5'-S-acetyl-N⁴-benzoyl-2',5'-dideoxy-5'-thiocytidine

: 177738-37-3
5’-S-acetyl-N-4-benzoyl-3’-O-(4,4-dimethoxytriphenyl)methyl-2’,5’-deoxy-5’-thiocytidine

Guidance literature:: With dmap; In pyridine; at 20 ℃; for 16h;
DOI:10.1002/anie.201310644

Reference yield:

: 4836-13-9
N₄-benzoyl-2'-deoxycytidine

: 177738-37-3
5’-S-acetyl-N-4-benzoyl-3’-O-(4,4-dimethoxytriphenyl)methyl-2’,5’-deoxy-5’-thiocytidine

Guidance literature:: Multi-step reaction with 2 steps

1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran; N,N-dimethyl-formamide / 16 h / 0 °C / Inert atmosphere

2: dmap / pyridine / 16 h / 20 °C

With dmap; di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; pyridine; N,N-dimethyl-formamide;
DOI:10.1002/anie.201310644