172161-64-7

Upstream product

• 4836-13-9 N₄-benzoyl-2'-deoxycytidine 
• 507-09-5 tiolacetic acid 

Downstream Products

• 172161-67-0 5'-S-acetyl-N⁴-benzoyl-3'-O-tert-butyldimethylsilyl-2',5'-dideoxy-5'-thiocytidine 
• 177738-39-5 N-4-benzoyl-3-O-(4,4-dimethoxytriphenyl)methyl-2,5-dideoxy-5-thiocytidine 
• 177738-37-3 5’-S-acetyl-N-4-benzoyl-3’-O-(4,4-dimethoxytriphenyl)methyl-2’,5’-deoxy-5’-thiocytidine 
• 172161-52-3 N⁴-benzoyl-3'-O-tert-butyldimethylsilyl-2',5'-dideoxy-5'-thiocytidine 

Relevant academic research and scientific papers

DNA with 3′-5′-disulfide links - Rapid chemical ligation through isosteric replacement

Efforts to chemically ligate oligonucleotides, without resorting to biochemical enzymes, have led to a multitude of synthetic analogues, and have extended oligomer ligation to reactions of novel oligonucleotides, peptides, and hybrids such as PNA.1 Key re

A versatile approach to the synthesis of oligonucleotide analogs containing neutral 5′-thioformacetal internucleoside linkages

Activation of nucleoside donors 5 by sulfuryl chloride followed by the addition of 5′-thionucleoside acceptors 3 yields 5′-thioformacetal dinucleotide analogs 6 with in situ trapping of liberated methanesulfenyl chloride with cyclohexene. Purine as well a

A versatile approach to the synthesis of dinucleotide analogs containing neutral 5'-thioformacetal internucleoside linkages

Activation of nucleoside donors 5 by sulfuryl chloride followed by the addition of 5'-thionucleoside acceptors 3 yields 5'-thioformacetal dinucleotide analogs 6 with in situ trapping of liberated methanesulfenyl chloride with cyclohexene. Purine as well as pyrimidine derivatives can be part of a coupling reaction as nucleoside donors or acceptors. The dimethoxytrityl protecting group is compatible with the present coupling methodology allowing differential 3',5'-end protection with concomitant orthogonal base protection.