(R)-N-allyl-2-(2-oxo-5-phenyl-3-piperidin-1-ylmethyl-2,3-dihydro-benzo[e][1,4]diazepin-1-yl)-acetamide

Base Information

Chemical Name:(R)-N-allyl-2-(2-oxo-5-phenyl-3-piperidin-1-ylmethyl-2,3-dihydro-benzo[e][1,4]diazepin-1-yl)-acetamide
CAS No.:1310683-91-0
Molecular Formula:C₂₆H₃₀N₄O₂
Molecular Weight:430.55
Hs Code.:

Synonyms:(R)-N-allyl-2-(2-oxo-5-phenyl-3-piperidin-1-ylmethyl-2,3-dihydro-benzo[e][1,4]diazepin-1-yl)-acetamide

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Chemical Property of (R)-N-allyl-2-(2-oxo-5-phenyl-3-piperidin-1-ylmethyl-2,3-dihydro-benzo[e][1,4]diazepin-1-yl)-acetamide

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Technology Process of (R)-N-allyl-2-(2-oxo-5-phenyl-3-piperidin-1-ylmethyl-2,3-dihydro-benzo[e][1,4]diazepin-1-yl)-acetamide

There total 4 articles about (R)-N-allyl-2-(2-oxo-5-phenyl-3-piperidin-1-ylmethyl-2,3-dihydro-benzo[e][1,4]diazepin-1-yl)-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1310683-88-5
(R)-(2-oxo-5-phenyl-3-piperidin-1-ylmethyl-2,3-dihydro-benzo[e][1,4]diazepin-1-yl)-acetic acid

: 107-11-9,30551-89-4
1-amino-2-propene

: 1310683-91-0
(R)-N-allyl-2-(2-oxo-5-phenyl-3-piperidin-1-ylmethyl-2,3-dihydro-benzo[e][1,4]diazepin-1-yl)-acetamide

Guidance literature:: With HATU; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 12h;
DOI:10.1016/j.ejmech.2011.02.058

Reference yield:

: 110-89-4
piperidine

: 1310683-91-0
(R)-N-allyl-2-(2-oxo-5-phenyl-3-piperidin-1-ylmethyl-2,3-dihydro-benzo[e][1,4]diazepin-1-yl)-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 2 h / 100 °C / Microwave irradiation

2: lithium hydroxide / methanol; water / 6 h / 0 - 20 °C

3: HATU / N,N-dimethyl-formamide / 12 h / 0 - 20 °C

With triphenylphosphine; HATU; lithium hydroxide; diethylazodicarboxylate; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; 1: Mitsunobu reaction;
DOI:10.1016/j.ejmech.2011.02.058

Reference yield:

: 896746-86-4
(R)-[3-(tert-butyl-dimethyl-silanyloxymethyl)-2-oxo-5-phenyl-2,3-dihydro-benzo[e][1,4]diazepin-1-yl]-acetic acid ethyl ester

: 1310683-91-0
(R)-N-allyl-2-(2-oxo-5-phenyl-3-piperidin-1-ylmethyl-2,3-dihydro-benzo[e][1,4]diazepin-1-yl)-acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 5 h / 20 °C

2: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 2 h / 100 °C / Microwave irradiation

3: lithium hydroxide / methanol; water / 6 h / 0 - 20 °C

4: HATU / N,N-dimethyl-formamide / 12 h / 0 - 20 °C

With tetrabutyl ammonium fluoride; triphenylphosphine; HATU; lithium hydroxide; diethylazodicarboxylate; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; 2: Mitsunobu reaction;
DOI:10.1016/j.ejmech.2011.02.058