(R)-[3-(tert-butyl-dimethyl-silanyloxymethyl)-2-oxo-5-phenyl-2,3-dihydro-benzo[e][1,4]diazepin-1-yl]-acetic acid ethyl ester

Base Information

Chemical Name:(R)-[3-(tert-butyl-dimethyl-silanyloxymethyl)-2-oxo-5-phenyl-2,3-dihydro-benzo[e][1,4]diazepin-1-yl]-acetic acid ethyl ester
CAS No.:896746-86-4
Molecular Formula:C₂₆H₃₄N₂O₄Si
Molecular Weight:466.652
Hs Code.:

Synonyms:(R)-[3-(tert-butyl-dimethyl-silanyloxymethyl)-2-oxo-5-phenyl-2,3-dihydro-benzo[e][1,4]diazepin-1-yl]-acetic acid ethyl ester

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Chemical Property of (R)-[3-(tert-butyl-dimethyl-silanyloxymethyl)-2-oxo-5-phenyl-2,3-dihydro-benzo[e][1,4]diazepin-1-yl]-acetic acid ethyl ester

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Technology Process of (R)-[3-(tert-butyl-dimethyl-silanyloxymethyl)-2-oxo-5-phenyl-2,3-dihydro-benzo[e][1,4]diazepin-1-yl]-acetic acid ethyl ester

There total 4 articles about (R)-[3-(tert-butyl-dimethyl-silanyloxymethyl)-2-oxo-5-phenyl-2,3-dihydro-benzo[e][1,4]diazepin-1-yl]-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 896746-85-3
(R)-3-(tert-butyl-dimethyl-silanyloxymethyl)-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one

: 105-36-2
ethyl bromoacetate

: 896746-86-4
(R)-[3-(tert-butyl-dimethyl-silanyloxymethyl)-2-oxo-5-phenyl-2,3-dihydro-benzo[e][1,4]diazepin-1-yl]-acetic acid ethyl ester

Guidance literature:: (R)-3-(tert-butyl-dimethyl-silanyloxymethyl)-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one; With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 1h;

ethyl bromoacetate; In N,N-dimethyl-formamide; at 20 ℃; for 12h; Further stages.;
DOI:10.1021/jm701141u

Reference yield:

: 896746-83-1
(R)-4-(2-benzoyl-phenylcarbamoyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

: 896746-86-4
(R)-[3-(tert-butyl-dimethyl-silanyloxymethyl)-2-oxo-5-phenyl-2,3-dihydro-benzo[e][1,4]diazepin-1-yl]-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 85 percent / HCl / methanol / 7 h / Heating

2.1: 87 percent / imidazole / CH₂Cl₂ / 12 h / 20 °C

3.1: NaH / dimethylformamide / 0.5 h / 20 °C

3.2: 78 percent / dimethylformamide / 5 h / 20 °C

With 1H-imidazole; hydrogenchloride; sodium hydride; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm060405f

Reference yield:

: 896746-84-2
(R)-3-hydroxymethyl-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one

: 896746-86-4
(R)-[3-(tert-butyl-dimethyl-silanyloxymethyl)-2-oxo-5-phenyl-2,3-dihydro-benzo[e][1,4]diazepin-1-yl]-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 87 percent / imidazole / CH₂Cl₂ / 12 h / 20 °C

2.1: NaH / dimethylformamide / 0.5 h / 20 °C

2.2: 78 percent / dimethylformamide / 5 h / 20 °C

With 1H-imidazole; sodium hydride; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm060405f